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TOXICITY OF DIMETHYL SULFOXIDE, ALONE AND IN COMBINATION

1975; Wiley; Volume: 243; Issue: 1 Linguagem: Inglês

10.1111/j.1749-6632.1975.tb25348.x

1749-6632

L.F. Rubin,

Inflammatory mediators and NSAID effects

Annals of the New York Academy of SciencesVolume 243, Issue 1 p. 98-103 TOXICITY OF DIMETHYL SULFOXIDE, ALONE AND IN COMBINATION Lionel F. Rubin, Lionel F. Rubin School of Veterinary Medicine University of Pennsylvania Philadelphia, PennsylvaniaSearch for more papers by this author Lionel F. Rubin, Lionel F. Rubin School of Veterinary Medicine University of Pennsylvania Philadelphia, PennsylvaniaSearch for more papers by this author First published: January 1975 https://doi.org/10.1111/j.1749-6632.1975.tb25348.xCitations: 37AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1Rubin, L. F. & P. A. Mattis. 1966. Dimethyl sulfoxide: Lens changes in dogs during oral administration. Science 153: 83–4. 2Smith, E. R., E. Hadidian & M. M. Mason. 1967. The single- and repeated-dose toxicity of dimethyl sulfoxide. Ann. N.Y. Acad. Sci. 141: 96–109. 3David, N. A. 1972. The pharmacology of dimethyl sulfoxide. Ann. Rev. Pharmacol. 12: 353–374. 4Brown, V. K., J. Robinson & D. E. Stevenson. 1963. A note on the toxicity and solvent properties of dimethyl sulfoxide. J. Pharm. Pharmacol. 15: 688–692. 5Sommer, S. & G. Tauberger. 1964. Toxicologic investigations of dimethyl sulfoxide. Arzneimittel-Forsch. 14: 1050–1053. 6Gordon, D. M. & K. E. Kleberger. 1968. The effect of dimethyl sulfoxide (DMSO) on animal and human eyes. Arch. Ophthalmol. (Chicago) 79: 423–7. 7Gerhards, E. & H. Gibian. 1967. The metabolism of dimethyl sulfoxide and its metabolic effects in man and animals. Ann. N.Y. Acad. Sci. 141: 65–76. 8Fishman, E. G., L. J. Jenkins, Jr., R. A. Coon & R. A. Jones. 1969. Effects of acute and repeated inhalation of dimethyl sulfoxide in rats. Toxicol. Appl. Pharmacol. 15: 74–82. 9 Anonymous. Dimethyl Sulfoxide (DMSO). A Summary of Toxicological and Safety Information. Crown Zellerbach Corporation, Chemical Products Division. Camas, Wash . 10Caujolle, F. M. E., D. H. Caujolle, S. B. Cros & M.-M. J. Calvet. 1967. Limits of toxic and teratogenic tolerance of dimethyl sulfoxide. Ann. N.Y. Acad. Sci. 141: 110–26. 11Jacob, S. W., E. E. Rosenbaum & D. C. Wood. 1971. Dimethyl Sulfoxide. Vol. 1. Basic Concepts of DMSO (Dimethyl Sulfoxide). Marcel Dekker. New York, N.Y . 12 National Academy of Sciences-National Research Council. 1973. Dimethyl sulfoxide as a therapeutic agent. Report of the ad hoc committee on dimethyl sulfoxide. 13Vogin, E. E., S. Carson, G. Cannon, C. R. Linegar & L. F. Rubin. 1970. Chronic toxicity of DMSO in primates. Toxicol. Appl. Pharmacol. 16: 606–12. 14Rubin, L. F. & K. C. Barnett. 1967. Ocular effects of oral and dermal application of dimethyl sulfoxide in animals. Ann. N.Y. Acad. Sci. 141: 333–45. 15Wood, D. C., F. S. Weber & M. A. Palmquist. 1971. Continued studies in the toxicology of dimethyl sulfoxide (DMSO). J. Pharmacol. Exp. Therap. 177: 520–7. 16Kramer, M. 1966. Zur Verhaglichkeit von DMSO bei Langdauernder Verabruchung in Tierversuch. In DMSO Symposium, Vienna, p. 6. Saladruck. Berlin, West Germany . 17Barnett, K. C. & P. R. Noel. 1967. Dimethyl sulphoxide and lens changes in primates. Nature 214: 115–6. 18Denko, C. W., R. M. Goodman, R. Miller & T. Donovan. 1967. Distribution of dimethyl sulfoxide-35S in the rat. Ann. N.Y. Acad. Sci. 141: 77–84. 19Husker, M. B., P. M. Ahmad & E. A. Miller. 1966. Absorption, distribution and metabolism of dimethyl-sulfoxide in the rat, rabbit and guinea pig. J. Pharmacol. Exp. Therap. 154: 176–84. 20Wood, D. C., D. Sweet & J. van Dolak. 1967. A study of DMSO and steroids in rabbits' eyes. Ann. N.Y. Acad. Sci. 141: 347–80. 21Wood, D. C., N. V. Wirth, F. S. Weber & M. A. Palmquist. 1971. Mechanism considerations of dimethyl sulfoxide (DMSO). Lenticular changes in rabbits. J. Pharmacol. Exp. Therap. 177: 528–35. 22Oliver, W. H., S. M. Shaw & J. E. Christian. 1969. Effect of dimethyl sulfoxide (DMSO) on the absorption of iron applied to piglets. Radiochem. Radioanal. Letters 2: 279–83. 23Djan, T. I. & D. L. Gunberg. 1967. Percutaneous absorption of two steroids dissolved in dimethyl sulfoxide in the immature female rat. Ann. N.Y. Acad. Sci. 141: 406–13. 24Maibach, H. I. & R. J. Feldmann. 1967. The effect of DMSO on percutaneous penetration of hydrocortisone and testosterone in man. Ann. N.Y. Acad. Sci. 141: 423–427. 25Feldmann, R. J. & H. I. Maibach. 1966. Percutaneous penetration of hydrocortisone- 14C in man. II. Effect of certain bases and pretreatments. Arch. Dermatol. 94: 649–51. 26Knowles, R. P. 1967. Clinical experience with DMSO in small animal practice. Ann. N.Y. Acad. Sci. 141: 478–483. 27Jacob, S. W., M. Bischel & R. J. Herschler. 1964. Dimethyl sulfoxide (DMSO): A new concept in pharmacotherapy. Current Therap. Res. 6: 134–5. 28Ben, M., R. L. Dixon, R. H. Adamson, H. Feinman & D. P. Rall. 1964. Toxicity of various drugs using dimethyl sulfoxide (DMSO) as a solvent. Pharmacologist 6: 189. 29Banthorpe, D. V. & D. M. Lamont. 1967. Potential toxicity of solutions of dimethyl sulphoxide. Nature 215: 1296–1297. 30Dachi, S. F., J. E. Sanders & E. M. Urie. 1967. Effects of dimethyl sulfoxide on dimethylbenzanthracene-induced carcinogenesis in the hamster cheek pouch. Cancer Res. 27: 1183–1185. 31Elzay, R. P. 1967. Dimethyl sulfoxide and experimental oral carcinogenesis in the hamster pouch. Arch. Pathol. 83: 293–297. 32Shklar, G., S. Turbiner & W. Siegel. 1969. Chemical carcinogenesis of hamster mucosa. Reaction to dimethyl sulfoxide. Arch. Pathol. 87: 637–642. Citing Literature Volume243, Issue1Biological Actions of Dimethyl SulfoxideJanuary 1975Pages 98-103 ReferencesRelatedInformation