The alkaline inactivation of botulinum toxin
1958; Elsevier BV; Volume: 73; Issue: 2 Linguagem: Inglês
10.1016/0003-9861(58)90291-1
ISSN1096-0384
Autores Tópico(s)Plant-based Medicinal Research
ResumoIn contrast to early observations on crude solutions of toxin, the purified toxin from Cl. botulinum, type A, was found to be quite stable at moderate alkalinity. The rate of inactivation increased by a factor of 4 × 104 over one pH unit above pH 10. Over a limited range, the inactivation rate was inversely proportional to the ninth power of the hydrogen-ion concentration. It is proposed that this rate is dependent upon the degree of a specific ionization and that the group involved is the ϵ-amino group of lysine.
Referência(s)