The mechanism of the rearrangement of the neurotoxin β-odap to α-odap
1994; Elsevier BV; Volume: 36; Issue: 1 Linguagem: Inglês
10.1016/s0031-9422(00)97018-3
ISSN1873-3700
AutoresAndré De Bruyn, Christian Becu, Fernand Lambein, Naod Kebede, Berhanu M. Abegaz, Peter B. Nunn,
Tópico(s)Biological Activity of Diterpenoids and Biflavonoids
ResumoThe diketopiperazine suggested to be the intermediate during the spontaneous isomerization of β-ODAP and α-ODAP was synthesized. Its behaviour was studied at selected pH values and provided evidence that its natural occurrence is unlikely. 2-Hydroxy-imidazolidine-2,4-dicarboxylic acid (for the rearrangement β-ODAP↔α-ODAP) or 2-hydroxy-pyrimidine-2,4-dicarboxylic acid (for the rearrangement Yγ-ODAB↔α-ODAB) are suggested to be the unstable intermediates.
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