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Prophylactic HPV vaccines: prospects for eliminating ano-genital cancer

2007; Springer Nature; Volume: 96; Issue: 9 Linguagem: Inglês

10.1038/sj.bjc.6603695

1532-1827

Margaret Stanley,

Hepatitis B Virus Studies

Virtually all cases of cervical cancer and its precursor intra-epithelial lesions are a result of infection with one or other of a subset of genital human papillomaviruses (HPVs), suggesting that prevention of HPV infection by prophylactic vaccination would be a highly effective anticancer strategy. Two HPV L1 virus-like particle vaccines have been developed, a quadrivalent HPV16/18/6/11 product and a bivalent HPV16/18 product; both have been shown to be highly immunogenic with a good safety profile and 100% efficacy against HPV16/18-related high-grade cervical intra-epithelial neoplasia (CIN2/3), implying that they will be effective at preventing HPV16/18-related cervical cancer.