Digitalis--a new controversy regarding an old drug. The pitfalls of inappropriate methods.
1986; Lippincott Williams & Wilkins; Volume: 73; Issue: 1 Linguagem: Inglês
10.1161/01.cir.73.1.14
ISSN1524-4539
AutoresSalim Yusuf, Janet Wittes, Kent R. Bailey, Curt D. Furberg,
Tópico(s)Atrial Fibrillation Management and Outcomes
ResumoHomeCirculationVol. 73, No. 1Digitalis--a new controversy regarding an old drug. The pitfalls of inappropriate methods. Free AccessAbstractPDF/EPUBAboutView PDFSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessAbstractPDF/EPUBDigitalis--a new controversy regarding an old drug. The pitfalls of inappropriate methods. S Yusuf, J Wittes, K Bailey and C Furberg S YusufS Yusuf , J WittesJ Wittes , K BaileyK Bailey and C FurbergC Furberg Originally published1 Jan 1986https://doi.org/10.1161/01.CIR.73.1.14Circulation. 1986;73:14–18 Previous Back to top Next FiguresReferencesRelatedDetailsCited By Anwar M, Khan U, Khakwani A, Saeed I, Ishfaq H, Muslim M and Anwaar M (2022) Digoxin Use in Atrial Fibrillation; Insights From National Ambulatory Medical Care Survey, Current Problems in Cardiology, 10.1016/j.cpcardiol.2022.101209, (101209), Online publication date: 1-Apr-2022. Ambrosy A, Bhatt A, Stebbins A, Wruck L, Fudim M, Greene S, Kraus W, O'Connor C, Piña I, Whellan D and Mentz R (2018) Prevalent digoxin use and subsequent risk of death or hospitalization in ambulatory heart failure patients with a reduced ejection fraction—Findings from the Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training (HF-ACTION) randomized controlled trial, American Heart Journal, 10.1016/j.ahj.2018.02.004, 199, (97-104), Online publication date: 1-May-2018. Duarte Vera Y, Cáceres Vinueza S, Daher Nader J and Lara Terán J (2018) Un novedoso agente en el tratamiento de la insuficiencia cardiaca con función sistólica deprimida, Archivos de Cardiología de México, 10.1016/j.acmx.2018.01.003, 88:4, (287-297), Online publication date: 1-Oct-2018. Ambrosy A, Pang P and Gheorghiade M (2016) Digoxin for Worsening Chronic Heart Failure, JACC: Heart Failure, 10.1016/j.jchf.2016.03.005, 4:5, (365-367), Online publication date: 1-May-2016. Wang Z, Zhang R, Chen M, Wang Q, Zhang Y, Huang X, Wang J, Yan J and Li Y (2015) Digoxin Is Associated With Increased All-cause Mortality in Patients With Atrial Fibrillation Regardless of Concomitant Heart Failure, Journal of Cardiovascular Pharmacology, 10.1097/FJC.0000000000000274, 66:3, (270-275), Online publication date: 1-Sep-2015. Khan S and Gheorghiade M (2015) Digoxin use in atrial fibrillation: a critical reappraisal, The Lancet, 10.1016/S0140-6736(14)62301-1, 385:9985, (2330-2332), Online publication date: 1-Jun-2015. Ambrosy A, Butler J, Ahmed A, Vaduganathan M, van Veldhuisen D, Colucci W and Gheorghiade M (2014) The Use of Digoxin in Patients With Worsening Chronic Heart Failure, Journal of the American College of Cardiology, 10.1016/j.jacc.2014.01.051, 63:18, (1823-1832), Online publication date: 1-May-2014. Tharwat M and Al-Sobayil F (2014) Influence of the cardiac glycoside digoxin on cardiac troponin I, acid–base and electrolyte balance, and haematobiochemical profiles in healthy donkeys (Equus asinus), BMC Veterinary Research, 10.1186/1746-6148-10-64, 10:1, (64), . van Veldhuisen D, Van Gelder I, Ahmed A and Gheorghiade M (2013) Digoxin for patients with atrial fibrillation and heart failure: paradise lost or not?, European Heart Journal, 10.1093/eurheartj/ehs483, 34:20, (1468-1470), Online publication date: 2-May-2013. Bahadir K, Serkan S, Hasan G, Ugur Onsel T, Emin A, Serdar A, Fatih A, Istemihan T and Ertugrul E (2012) Digoxin intoxication: An old enemy in modern era, Journal of Geriatric Cardiology, 10.3724/SP.J.1263.2012.01101, 9:3, (237-242), Online publication date: 27-Nov-2012. Goldberger Z and Goldberger A (2012) Therapeutic Ranges of Serum Digoxin Concentrations in Patients With Heart Failure, The American Journal of Cardiology, 10.1016/j.amjcard.2012.02.028, 109:12, (1818-1821), Online publication date: 1-Jun-2012. Califf R and Harrington R (2011) American Industry and the U.S. Cardiovascular Clinical Research Enterprise, Journal of the American College of Cardiology, 10.1016/j.jacc.2011.03.048, 58:7, (677-680), Online publication date: 1-Aug-2011. Thompson P (2011) Management of the postcoronary patient Coronary Care Manual, 10.1016/B978-0-7295-3927-2.10090-9, (650-659), . Castiella E, Frechilla D, Lasheras B, Cenarruzabeitia E, Martínez De Irujo J, Alberdi E, Santiago E, Monge A, Villanueva A, Martinez F and Font M (2011) Inotropic and Chronotropic Effects of 4-(4′- n -Butylaniline)-7,8-dimethoxy-5H-pyrimido[5,4– b ]indole in Guinea-pig Atria , Journal of Pharmacy and Pharmacology, 10.1111/j.2042-7158.1995.tb06722.x, 47:7, (601-607), Online publication date: 12-Apr-2011. Thompson P (2011) Diuretics, digitalis, and electrolytes Coronary Care Manual, 10.1016/B978-0-7295-3927-2.10037-5, (277-284), . Brinkley J, Tsiatis A and Anstrom K (2009) A Generalized Estimator of the Attributable Benefit of an Optimal Treatment Regime, Biometrics, 10.1111/j.1541-0420.2009.01282.x, 66:2, (512-522), Online publication date: 1-Jun-2010. Vítovec J and Špinar J (2009) Heart-rate slowing drugs in the treatment of myocardial infarction survivors, Cor et Vasa, 10.33678/cor.2009.026, 51:2, (97-102), Online publication date: 1-Feb-2009. Abouzid K, Abdel Hakeem M, Khalil O and Maklad Y (2008) Pyridazinone derivatives: Design, synthesis, and in vitro vasorelaxant activity, Bioorganic & Medicinal Chemistry, 10.1016/j.bmc.2007.09.031, 16:1, (382-389), Online publication date: 1-Jan-2008. Bekhit A and Baraka A (2005) Novel milrinone analogs of pyridine-3-carbonitrile derivatives as promising cardiotonic agents, European Journal of Medicinal Chemistry, 10.1016/j.ejmech.2005.06.005, 40:12, (1405-1413), Online publication date: 1-Dec-2005. Collins J, Egan D, Yusuf S, Garg R, Williford W, Geller N and on behalf of the DIG Investigators (2003) Overview of the DIG trial, Controlled Clinical Trials, 10.1016/S0197-2456(03)00104-1, 24:6, (S269-S276), Online publication date: 1-Dec-2003. Padrini , Panfili , Magnolfi , Piovan , Casarotto and Ferrari (2001) Myocardial region (right or left ventricle) and aetiology of heart failure can influence the inotropic effect of ouabain in failing human myocardium, British Journal of Clinical Pharmacology, 10.1046/j.1365-2125.1999.00064.x, 48:5, (743-749), Online publication date: 1-Nov-1999. Abadi A, Al-Deeb O, Al-Afify A and El-Kashef H (1999) Synthesis of 4-alkyl (aryl)-6-aryl-3-cyano-2(1H)-pyridinones and their 2-imino isosteres as nonsteroidal cardiotonic agents, Il Farmaco, 10.1016/S0014-827X(99)00004-X, 54:4, (195-201), Online publication date: 1-Apr-1999. Friedman L (1998) β-blockers are under-utilized in elderly patients after MI, Evidence-based Cardiovascular Medicine, 10.1016/S1361-2611(98)80049-3, 2:4, (109-110), Online publication date: 1-Dec-1998. McDermott M, Feinglass J, Lee P, Mehta S, Schmitt B, Lefevre F, Puppala J and Gheorghiade M (1997) Heart failure between 1986 and 1994: Temporal trends in drug-prescribing practices, hospital readmissions, and survival at an academic medical center, American Heart Journal, 10.1016/S0002-8703(97)80013-0, 134:5, (901-909), Online publication date: 1-Nov-1997. MacMahon S, Collins R and Chalmers J (1997) Reliable and unbiased assessment of the effects of calcium antagonists, Journal of Hypertension, 10.1097/00004872-199715110-00002, 15:11, (1201-1204), Online publication date: 1-Nov-1997. (1997) The Effect of Digoxin on Mortality and Morbidity in Patients with Heart Failure, New England Journal of Medicine, 10.1056/NEJM199702203360801, 336:8, (525-533), Online publication date: 20-Feb-1997. (2009) Effects of Calcium Antagonists on the Risks of Coronary Heart Disease, Cancer and Bleeding, Blood Pressure, 10.3109/08037059709061929, 6:3, (134-146), Online publication date: 1-Jan-1997. Gheorghiade M and Pitt B (1997) Digitalis Investigation Group (DIG) trial: A stimulus for further research, American Heart Journal, 10.1016/S0002-8703(97)70100-5, 134:1, (3-12), Online publication date: 1-Jul-1997. Packer M (1997) End of the Oldest Controversy in Medicine — Are We Ready to Conclude the Debate on Digitalis?, New England Journal of Medicine, 10.1056/NEJM199702203360809, 336:8, (575-576), Online publication date: 20-Feb-1997. Smith J, Frawley P and Polissar N (1997) Six- and Twelve-Month Abstinence Rates in Inpatient Alcoholics Treated with Either Faradic Aversion or Chemical Aversion Compared with Matched Inpatients, Journal of Addictive Diseases, 10.1300/J069v16n01_02, 16:1, (5-24), Online publication date: 4-Feb-1997. van VELDHUISEN D, de GRAEFF P, REMME W and LIE K (1996) Value of Digoxin in Heart Failure and Sinus Rhythm: New Features of an Old Drug?, Journal of the American College of Cardiology, 10.1016/S0735-1097(96)00247-1, 28:4, (813-819), Online publication date: 1-Oct-1996. Théry C, Asseman P, Bauchart J and Loubeyre C (1996) Actualités sur le traitement de l'insuffisance cardiaque chronique, La Revue de Médecine Interne, 10.1016/0248-8663(96)82963-8, 17:2, (135-143), Online publication date: 1-Feb-1996. Leor J, Goldbourt U, Rabinowitz B, Reicher-Reiss H, Boyko V, Kaplinsky E and Behar S (1995) Digoxin and increased mortality among patients recovering from acute myocardial infarction: Importance of digoxin dose, Cardiovascular Drugs and Therapy, 10.1007/BF00878556, 9:5, (723-729), Online publication date: 1-Oct-1995. Leor J, Goldbourt U, Behar S, Boyko V, Reicher-Reiss H, Kaplinsky E and Rabinowitz B (1995) Digoxin and mortality in survivors of acute myocardial infarction: Observations in patients at low and intermediate risk, Cardiovascular Drugs and Therapy, 10.1007/BF00878094, 9:4, (609-617), Online publication date: 1-Aug-1995. Leor J, Goldbourt U and Behar S (1995) Is it safe to prescribe digoxin after acute myocardial infarction? Update on continued controversy, American Heart Journal, 10.1016/0002-8703(95)90186-8, 130:6, (1322-1326), Online publication date: 1-Dec-1995. Domanski M, Garg R and Yusuf S (1994) Prognosis in Congestive Heart Failure Congestive Heart Failure, 10.1007/978-1-4613-8315-4_33, (622-627), . Young J (1994) Do Digitalis Glycosides Still Have a Role in Congestive Heart Failure?, Cardiology Clinics, 10.1016/S0733-8651(18)30125-5, 12:1, (51-62), Online publication date: 1-Feb-1994. Bigger J (1994) Diuretic Therapy, Hypertension, and Cardiac Arrest, New England Journal of Medicine, 10.1056/NEJM199406303302613, 330:26, (1899-1900), Online publication date: 30-Jun-1994. Poole Wilson P (1993) Digoxin?Doubts to dampen enthusiasm, Cardiovascular Drugs and Therapy, 10.1007/BF00877723, 7:6, (897-898), Online publication date: 1-Dec-1993. Marcus F (1993) Digoxin is effective, but is it safe?, Cardiovascular Drugs and Therapy, 10.1007/BF00877722, 7:6, (893-896), Online publication date: 1-Dec-1993. Dietz R (1992) Therapie — Behandlung früher und heute (Stufenplan) Herzinsuffizienz, 10.1007/978-3-642-77021-0_20, (203-213), . Gheorghiade M and Zarowitz B (1992) Review of randomized trials of digoxin therapy in patients with chronic heart failure, The American Journal of Cardiology, 10.1016/0002-9149(92)91254-2, 69:18, (48-63), Online publication date: 1-Jun-1992. Yusuf S, Garg R, Held P and Gorlin R (1992) Need for a large randomized trial to evaluate the effects of digitalis on morbidity and mortality in congestive heart failure, The American Journal of Cardiology, 10.1016/0002-9149(92)91255-3, 69:18, (64-70), Online publication date: 1-Jun-1992. Montanari P, Chiarini A, Budriesi R and Valenti P (1992) Xanthone analogues of milrinone, Journal of Heterocyclic Chemistry, 10.1002/jhet.5570290149, 29:1, (259-261), Online publication date: 1-Jan-1992. Gibaldi M (2016) Adverse Drug Effects: Part II, Annals of Pharmacotherapy, 10.1177/106002809202600419, 26:4, (550-554), Online publication date: 1-Apr-1992. Pitt B, Cohn J, Francis G, Kostis J, Packer M, Pfeffer M, Swedberg K and Yusuf S (1992) The effect of treatment on survival in congestive heart failure, Clinical Cardiology, 10.1002/clc.4960150504, 15:5, (323-329), Online publication date: 1-May-1992. Knight D (1991) Efficacy of Inotropic Support of the Failing Heart, Veterinary Clinics of North America: Small Animal Practice, 10.1016/S0195-5616(91)50101-7, 21:5, (879-904), Online publication date: 1-Sep-1991. Schleifer S, Slater W, Macari-Hinson M, Coyle D, Kahn M, Zucker H and Gorlin R (1991) Digitalis and β-blocking agents: Effects on depression following myocardial infarction, American Heart Journal, 10.1016/0002-8703(91)90144-7, 121:5, (1397-1402), Online publication date: 1-May-1991. YUSUF S, GARG R and ZUCKER D (1991) Analyses by the Intention-to-Treat Principle in Randomized Trials and Databases, Pacing and Clinical Electrophysiology, 10.1111/j.1540-8159.1991.tb06476.x, 14:12, (2078-2082), Online publication date: 1-Dec-1991. Calvert C (1991) Effect of Medical Therapy on Survival of Patients with Dilated Cardiomyopathy, Veterinary Clinics of North America: Small Animal Practice, 10.1016/S0195-5616(91)50103-0, 21:5, (919-930), Online publication date: 1-Sep-1991. Erlemeier H and Bleifeld W (1991) Effects of Different Positive Inotropic Drugs in Congestive Heart Failure Heart Failure Mechanisms and Management, 10.1007/978-3-642-58231-8_21, (205-210), . Smith J, Frawley P and Polissar L (1991) Six- and Twelve-Month Abstinence Rates in Inpatient Alcoholics Treated with Aversion Therapy Compared with Matched Inpatients from a Treatment Registry, Alcoholism: Clinical and Experimental Research, 10.1111/j.1530-0277.1991.tb00614.x, 15:5, (862-870), Online publication date: 1-Oct-1991. Pouleur H (1990) Possible Role of Positive Inotropic Drugs in Congestive Heart Failure and in Left Ventricular Dysfunction Heart Failure and Arrhythmias, 10.1007/978-3-642-75326-8_10, (76-82), . Weber S, Kahan A, Pinquier J, Julien J, Rosenzweig P, Bianchetti G, Morselli P, Dessault O, Lauture D and Strauch G (2012) Pharmacodynamic without pharmacokinetic interaction between cicloprolol, a partial beta 1-adrenoceptor agonist, and digoxin in healthy subjects., British Journal of Clinical Pharmacology, 10.1111/j.1365-2125.1990.tb03792.x, 30:3, (411-416), Online publication date: 1-Sep-1990. HERLITZ J, KARLSON B and HJALMARSON Å (1990) Mortality and morbidity during one year of follow-up in suspected acute myocardial infarction in relation to early diagnosis: experiences from the MIAMI trial, Journal of Internal Medicine, 10.1111/j.1365-2796.1990.tb00205.x, 228:2, (125-131), Online publication date: 1-Aug-1990. Volpi A, Cavalli A, Santoro E and Tognoni G (1990) Incidence and prognosis of secondary ventricular fibrillation in acute myocardial infarction. Evidence for a protective effect of thrombolytic therapy. GISSI Investigators., Circulation, 82:4, (1279-1288), Online publication date: 1-Oct-1990. Poole-Wilson P and Robinson K (1989) Digoxin?A redundant drug in congestive cardiac failure, Cardiovascular Drugs and Therapy, 10.1007/BF00133201, 2:6, (733-741), Online publication date: 1-Jan-1989. Packer M (1989) Does digitalis work in chronic heart failure? The end of a 200-year-old controversy, Cardiovascular Drugs and Therapy, 10.1007/BF00133202, 2:6, (743-746), Online publication date: 1-Jan-1989. DiBianco R, Shabetai R, Kostuk W, Moran J, Schlant R and Wright R (1989) A Comparison of Oral Milrinone, Digoxin, and Their Combination in the Treatment of Patients with Chronic Heart Failure, New England Journal of Medicine, 10.1056/NEJM198903163201101, 320:11, (677-683), Online publication date: 16-Mar-1989. Pitt B and Goldstein S (1989) The captopril-digoxin multicenter resarch group study on the comparative steps of captopril and digoxin in patients with mildmoderate heart failure: Implications for therapy, Cardiovascular Drugs and Therapy, 10.1007/BF01881521, 3:1, (7-9), Online publication date: 1-Jan-1989. Cavalli A, Riva E, Schleman M, Abbondati G, Fuccella L and Kline S (1989) Ibopamine as a substitute for digitalis in patients with congestive heart failure on chronic digoxin therapy, International Journal of Cardiology, 10.1016/0167-5273(89)90280-5, 22:3, (381-387), Online publication date: 1-Mar-1989. Hayward R (1988) Digitalis and arrhythmias Clinical Aspects of Cardiac Arrhythmias, 10.1007/978-94-009-1289-2_19, (311-335), . Kimmelstiel C and Benotti J (1988) How effective is digitalis in the treatment of congestive heart failure?, American Heart Journal, 10.1016/0002-8703(88)90161-5, 116:4, (1063-1070), Online publication date: 1-Oct-1988. Pitt B (1988) III. Antagonist's viewpoint, Journal of the American College of Cardiology, 10.1016/0735-1097(88)90387-7, 12:1, (271-273), Online publication date: 1-Jul-1988. Smith T (1988) II. Protagonist's viewpoint, Journal of the American College of Cardiology, 10.1016/0735-1097(88)90386-5, 12:1, (267-271), Online publication date: 1-Jul-1988. Young J, Leon C and Pratt C (1987) Potentially Deleterious Effects of Long-term Vasodilator Therapy in Patients with Heart Failure, Chest, 10.1378/chest.91.5.737, 91:5, (737-744), Online publication date: 1-May-1987. Fleiss J, Bigger J and Rolnitzky L (1986) Is catch-22 alive and well and living at NHLBI? Reactions to 'digitalis--a new controversy regarding an old drug'., Circulation, 73:1, (19-20), Online publication date: 1-Jan-1986.Califf R, Pryor D and Greenfield J (1986) Beyond randomized clinical trials: applying clinical experience in the treatment of patients with coronary artery disease., Circulation, 74:6, (1191-1194), Online publication date: 1-Dec-1986. January 1, 1986Vol 73, Issue 1 Advertisement Article InformationMetrics Copyright © 1986 by American Heart Associationhttps://doi.org/10.1161/01.CIR.73.1.14 Originally publishedJanuary 1, 1986 PDF download Advertisement
Referência(s)