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Chromosomal orientation of the lambda light chain locus: Vλ is proximal to Cλ in 22q11

1985; Oxford University Press; Volume: 13; Issue: 2 Linguagem: Inglês

10.1093/nar/13.2.381

1362-4962

Beverly S. Emanuel, Linda A. Cannizzaro, I T Magrath, Yoshihide Tsujimoto, Peter C. Nowell̀, Carlo M. Croce,

Kruppel-like factors research

We have demonstrated that the chromosomal breakpoint at 22q11 of a Burkitt lymphoma cell line (PA682) with an 8;22 translocation interrupts the variable region of the lambda light chain locus. In these cells, all of the Cλ and some Vλ sequences translocate to the 8q+ chromosome whereas some Vλ sequences remain on the 22q−. These results indicate that the lambda light chain locus on the long arm of chromosome 22 is oriented such that Vλ is proximal to Cλ.