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First Description of KPC-2-Producing Klebsiella oxytoca in Brazil

2013; American Society for Microbiology; Volume: 57; Issue: 8 Linguagem: Inglês

10.1128/aac.02376-12

1098-6596

Anna Almeida, Felipe Lira de Sá Cavalcanti, Willames M. B. S. Martins, Marinalda Anselmo Vilela, Ana Cristina Gales, Marcos Antônio de Morais, Márcia Maria Camargo de Morais,

Pharmaceutical and Antibiotic Environmental Impacts

The present work reports the detection of the first case of nosocomial Klebsiella oxytoca producing class A carbapenemase KPC-2 in Brazil. The isolate KPN106 carried a 65-kb IncW-type plasmid that harbors the blaKPC gene and Tn4401b. Moreover, we detected the presence of a class 1 integron containing a new allele, arr-8, followed by a 5'-truncated dhfrIIIc gene. In view of the recent results, we emphasize the high variability of the bacterial and genetic hosts of this resistance determinant.