Produção Nacional
Revisado por pares
Pilot survey of commercial pasteurized milk consumed in the metropolitan area of Rio de Janeiro, Brazil, for tetracyclines residues, including the 4-epimers of oxytetracycline, tetracycline and chlortetracycline
2010; Taylor & Francis; Volume: 3; Issue: 4 Linguagem: Inglês
10.1080/19393210.2010.531401
ISSN1939-3229
AutoresBernardete Ferraz Spisso, Mychelle Alves Monteiro, Mararlene Ulberg Pereira, Rosana Gomes Ferreira, Rafaela Pinto da Costa, Tatiana Ávila Cruz, Armi Wanderley da Nóbrega,
Tópico(s)Biosensors and Analytical Detection
ResumoThis pilot survey aimed to assess the occurrence of tetracyclines and the 4-epimers of oxytetracycline, tetracycline and chlortetracycline in commercial pasteurized milks sold in the metropolitan area of Rio de Janeiro, Brazil, between October 2009 and March 2010. A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method, developed and validated in our laboratory, was used. All 100 analyzed samples were compliant, but 14 contained oxytetracycline in concentrations ranging from the method limit of detection (3.7 µg l(-1)) to the method limit of quantification (12.2 µg l(-1)). One sample contained oxytetracycline and tetracycline simultaneously (at a concentration slightly higher than method limit of quantification, 7.0 µg l(-1)). The presence of 4-epioxytetracycline and 4-epitetracycline in contaminated samples with the parent drugs could not be confirmed as traces were detected only in the quantification MRM transition. No other tetracyclines were detected.
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