Produção Nacional
Revisado por pares
A systematic review and meta-analysis of cohort studies of echocardiographic findings in OSA children after adenotonsilectomy
2014; Elsevier BV; Volume: 78; Issue: 10 Linguagem: Inglês
10.1016/j.ijporl.2014.07.021
ISSN1872-8464
AutoresSilke Anna Theresa Weber, Raíssa Pierri Carvalho, Greta Ridley, Katrina Williams, Regina El Dib,
Tópico(s)Congenital Heart Disease Studies
ResumoThere is evidence that OSA in children can be associated with acute and chronic effects on the cardiovascular system due to repetitive episodes of apnea and hypoxemia.To assess whether there is an association between OSA and echocardiographic findings in children and whether that association persists after adenotonsillectomy.A literature search was conducted based on PUBMED, EMBASE and LILACS.Children with OSA and children who did not have OSA, who were aged ≤12 years.Two reviewers extracted data independently; the risk of bias was assessed by examining the selected sample, the recruitment method, completeness of follow up, and blinding.Seven studies met all the inclusion criteria and methodological requirements. There was a significant difference with elevated mean pulmonary arterial pressure levels in OSA participants compared to those without OSA at preoperative assessment [mean difference (MD) 8.67; confidential interval (CI) 95% 6.09, 11.25]. OSA participants showed a statistically significant increased interventricular septum (IVS) thickness (mm) [MD 0.60; CI 95% 0.09, 1.11]; and right ventricular (RV) dimension (cm/m) [MD 0.19; CI 95% 0.10, 0.28]. There was also a significant increase in right ventricular (RV) dimension (cm/m) [MD 0.10; CI 95% 0.05, 0.14] in OSA children.There is moderate quality evidence regarding possible association between OSA and right heart repercussions. More prognosis studies are needed, to allow the combination of results in a meta-analysis.
Referência(s)