Enzymatic synthesis of 11C-pyruvic acid and 11C-L-lactic acid
1980; Pergamon Press; Volume: 31; Issue: 1 Linguagem: Inglês
10.1016/0020-708x(80)90229-x
ISSN1878-1284
AutoresMarvin B. Cohen, Leonard Spolter, Chia‐Chun Chang, Joseph S. Cook, Norman S. MacDonald,
Tópico(s)ATP Synthase and ATPases Research
ResumoL-Lactic acid is formed as the end product of glycolysis under anaerobic conditions in all cells, but this reaction is of special significance in the myocardium. L-Lactic acid is reversibly formed from and is in equilibrium with myocardial pyruvic acid, which is its sole metabolic pathway. 11C-Pyruvic acid is synthesized from 11C carbon dioxide using pyruvate-ferredoxin oxidoreductase and coenzymes. The 11C-pyruvic acid is then converted to 11C-L-lactic acid by lactic acid dehydrogenase. The availability of 11C-pyruvic acid and 11C-L-lactic acid will permit the in vivo investigation of lactate metabolism.
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