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BIBTEX RIS

Palladium-catalyzed cross-coupling of N-benzenesulfonyl-3,4-dibromopyrrole and its application to the total syntheses of lamellarins O, P, Q, and R

2007; Elsevier BV; Volume: 64; Issue: 2 Linguagem: Inglês

10.1016/j.tet.2007.10.105

ISSN

1464-5416

Autores

Tsutomu Fukuda, Eiichi Sudo, Kozue Shimokawa, Masatomo Iwao,

Tópico(s)

Catalytic C–H Functionalization Methods

Resumo

Palladium-catalyzed Suzuki–Miyaura coupling of N-benzenesulfonyl-3,4-dibromopyrrole with a variety of arylboronic acids gave the corresponding 3,4-diarylpyrroles in high yields. The 3,4-differentially arylated pyrroles could also be prepared by stepwise cross-coupling approach. The total syntheses of lamellarins O, P, Q, and R have been achieved by using the cross-coupling and the directed lithiation as key reactions.

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