Blood glucose and neurologic outcome with global brain ischemia
1996; Lippincott Williams & Wilkins; Volume: 24; Issue: 5 Linguagem: Inglês
10.1097/00003246-199605000-00013
ISSN1530-0293
AutoresJay S. Steingrub, Diane J. Mundt,
Tópico(s)Sepsis Diagnosis and Treatment
ResumoTo investigate the relationship between neurologic outcome and blood glucose concentrations in survivors of cardiopulmonary arrest.Retrospective case series chart review.Adult multidisciplinary intensive care unit (ICU) of a tertiary referral medical center.Consecutive patients over a 12-month period surviving cardiopulmonary resuscitation (CPR).Variables that were examined that could affect the relationship between the circulating glucose concentration and neurologic outcome included: location of arrest (inhospital/out-of-hospital), age, history of diabetes mellitus, duration of arrest, CPR duration, initial cardiac rhythm, and drugs administered during arrest. Cerebral recovery was evaluated by a 5-point outcome scale (Glasgow Pittsburgh Brain Stem Score) on ICU admission, and 24 and 48 hrs after ICU admission.Observations were made on 85 patients, of whom 67% had inpatient CPR and 33% received out-of-hospital CPR. The duration of arrest of 66 (78%) patients was 5 min.The present study does not support an association between the concentration of glucose post-CPR and neurologic outcome. The previously reported casual relationship between hyperglycemia and neurologic prognosis may be an epiphenomenon of the severity of global cerebral ischemia in humans.
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