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Biologically Driven Synthesis of Pyrazolo[3,4- d ]pyrimidines As Protein Kinase Inhibitors: An Old Scaffold As a New Tool for Medicinal Chemistry and Chemical Biology Studies

2014; American Chemical Society; Volume: 114; Issue: 14 Linguagem: Inglês

10.1021/cr400270z

1520-6890

Silvia Schenone, Marco Radi, Francesca Musumeci, Chiara Brullo, Maurizio Botta,

Synthesis and Reactivity of Heterocycles

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTBiologically Driven Synthesis of Pyrazolo[3,4-d]pyrimidines As Protein Kinase Inhibitors: An Old Scaffold As a New Tool for Medicinal Chemistry and Chemical Biology StudiesSilvia Schenone*†, Marco Radi‡, Francesca Musumeci†, Chiara Brullo†, and Maurizio Botta§⊥View Author Information† Dipartimento di Farmacia, Università degli Studi di Genova Viale Benedetto XV, 3, 16132 Genova, Italy‡ Dipartimento di Farmacia, Università degli Studi di Parma Viale delle Scienze, 27/A, 43124 Parma, Italy§ Dipartimento di Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena Via Aldo Moro, 2, 53100 Siena, Italy⊥ Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, BioLife Science Building, Suite 333, 1900 N 12th Street, Philadelphia, Pennsylvania 19122, United States*E-mail: [email protected]. Phone: +39 010 3538362. Fax: +39 010 3538358.Cite this: Chem. Rev. 2014, 114, 14, 7189–7238Publication Date (Web):May 29, 2014Publication History Received16 May 2013Published online29 May 2014Published inissue 23 July 2014https://pubs.acs.org/doi/10.1021/cr400270zhttps://doi.org/10.1021/cr400270zreview-articleACS PublicationsCopyright © 2014 American Chemical SocietyRequest reuse permissionsArticle Views4132Altmetric-Citations114LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Assays,Inhibition,Inhibitors,Peptides and proteins,Reaction products Get e-Alerts