A 2-hit model for chronic GVHD
2013; Elsevier BV; Volume: 122; Issue: 5 Linguagem: Inglês
10.1182/blood-2013-06-507376
ISSN1528-0020
Autores Tópico(s)Urinary Bladder and Prostate Research
ResumoIn this issue of Blood, Dertschnig and colleagues1 demonstrate in mice that acute graft-versus-host disease (GHVD) results in a marked reduction of autoimmune receptor–expressing medullary thymic epithelial cells (Aire1 mTEC) and a decrease in the diversity of Aire-dependent tissue-restricted peripheral selfantigens (TRAs) required for effective negative thymic selection. Both of these abnormalities are reversed by the peritransplant administration of the epithelial protectant drug, fibroblast growth factor 7(Fgf7).
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