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Intravenous adenosine for refractory pulmonary hypertension in a low-weight premature newborn: A potential new drug for rescue therapy

2006; Lippincott Williams & Wilkins; Volume: 7; Issue: 4 Linguagem: Inglês

10.1097/01.pcc.0000225000.78627.eb

1947-3893

Alessandro Motti, C cile Tissot, Peter C. Rimensberger, Aline Prina-Rousso, Yacine Aggoun, Michel Berner, Maurice Beghetti, Eduardo M. da Cruz,

Mechanical Circulatory Support Devices

Objectives: To use intravenous adenosine as a rescue therapy for neonatal refractory pulmonary hypertension in a low-weight premature infant. Study Line: We report the successful use of a continuous intravenous adenosine infusion in a 1150-g premature baby with severe persistent pulmonary hypertension, refractory to classic management with high-frequency oscillatory ventilation, oxygen therapy and inhaled nitric oxide. Results: Adenosine infusion had a dramatic effect allowing for a rapid weaning of oxygen, ventilatory variables, and nitric oxide. Conclusions: Although experience with continuous adenosine infusion is still at an early stage, it might be worth considering its administration as a rescue therapy or even as an alternative to extracorporeal membrane oxygenation.