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Occupational Immunoglobulin E-Mediated Asthma due to <i>Penicillium camemberti</i> in a Dry-Sausage Packer

2006; Karger Publishers; Volume: 76; Issue: 1 Linguagem: Inglês

10.1159/000097137

1423-0356

R. Merget, Ingrid Sander, P. Rozynek, Evelyn Heinze, M. Imoehl, Monika Raulf, Thomas Bruening,

Medical Device Sterilization and Disinfection

A 62-year-old female sausage packer reported progressive work-related asthma, rhinitis and contact urticaria after contact to dry sausages refined by moulds. Whereas skin prick tests with commercial mould extracts were negative, the patient showed weak skin sensitization to a cultivated mould sample from a dry sausage. Specific immunoglobulin E antibodies to various moulds were demonstrated by ImmunoCAP and antibodies to the cultivated mould sample were demonstrated by enzyme allergosorbent test. The mould was identified by pheno- and genotyping as <i>Penicillium camemberti.</i> Five atopic controls did not show sensitization with the same tests. Crossreactivity of <i>P. camemberti</i> and <i>Penicillium notatum</i> was shown by enzyme allergosorbent inhibition tests. Although no challenge tests were considered due to the patient’s airway obstruction, a diagnosis of allergic occupational asthma was made. We conclude that immunoglobulin E-mediated allergic occupational asthma due to moulds may occur in dry sausage packers.