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Renal injury from valproic acid: case report and literature review

2002; Elsevier BV; Volume: 27; Issue: 4 Linguagem: Inglês

10.1016/s0887-8994(02)00447-2

1873-5150

Emad L. Zaki, James E. Springate,

Bipolar Disorder and Treatment

A child with developmental delay and epilepsy developed glucosuria approximately 16 months after starting valproic acid therapy. Laboratory evaluation revealed global defects in proximal tubule function consistent with the De Toni-Debré-Fanconi syndrome. Discontinuation of valproate led to complete recovery 5 months later. Review of previously reported cases indicates that this complication is unique to children and reversible when the medication is discontinued.