Selectins: Interpreters of Cell-Specific Carbohydrate Information During Inflammation
1992; American Association for the Advancement of Science; Volume: 258; Issue: 5084 Linguagem: Inglês
10.1126/science.1439808
ISSN1095-9203
Autores Tópico(s)Monoclonal and Polyclonal Antibodies Research
ResumoAlthough a bewildering array of cell surface carbohydrate structures have been described, the physiological relevance of any of these complex molecules has often eluded biologists. A family of cell surface glycoproteins, the "selectins," has a characteristic ability to use some of these carbohydrate structures in adhesive mechanisms that help localize leukocytes to regions of inflammation. This article will review the biology of these carbohydrate-binding adhesive proteins and discuss the potential for developing anti-inflammatory antagonists that could inhibit binding events that are selectin-mediated.
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