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Multiple ?serrated adenocarcinomas? of the colon with a cell lineage common to metaplastic polyp and serrated adenoma. Case report of a new subtype of colonic adenocarcinoma with gastric differentiation

2000; Volume: 190; Issue: 4 Linguagem: Inglês

10.1002/(sici)1096-9896(200003)190

1096-9896

Takashi Yao, Kenichi Nishiyama, Masafumi Oya, Toshio Kouzuki, Masaaki Kajiwara, Masazumi Tsuneyoshi,

Gastric Cancer Management and Outcomes

A 70-year-old woman underwent right hemicolectomy and six carcinomas were recognized in the resected colon. These carcinomas were considered to be of a cell lineage common to serrated adenoma (SA) and hyperplastic (metaplastic) polyp (H/MP), because of the occurrence of multiple SAs and H/MPs around the carcinomas, as well as the co-existence of SA and H/MP areas within the carcinomas. These carcinomas had the following common histological and immunohistochemical features: a serrated structure resembling SA; a lace-like structure; infiltrative growth within the muscularis propria, with dedifferentiation at the invasive front; and immunohistochemical expression of pS2 and human gastric mucin. Based on these features, a new subtype of carcinoma is proposed, with a cell lineage common to SA and H/MP. It would also seem that p53 is involved in the serrated adenoma–carcinoma sequence. Copyright © 2000 John Wiley & Sons, Ltd.