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The Anti-inflammatory and Anti-nociceptive Effects of Ethyl Acetate Fraction of Cynanchi Paniculati Radix

2006; Pharmaceutical Society of Japan; Volume: 29; Issue: 5 Linguagem: Inglês

10.1248/bpb.29.971

1347-5215

Jung‐Hyun Choi, Byung-Ha Jung, Ok‐Hwa Kang, Hyuk Joon Choi, Pil Sang Park, Sun Hee Cho, Youn‐Chul Kim, Dong Hwan Sohn, Hyun Park, John Hwa Lee, Dong‐Yeul Kwon,

Phytochemical compounds biological activities

The anti-inflammatory and anti-nociceptive effects and sedative activities of the ethyl acetate fraction of Cynanchum paniculatum (EACP) were evaluated in mice and rats by acetic acid-induced vascular permeability, arachidonic acid-induced paw edema, cotton pellet-induced granuloma formation, formalin-induced licking time, acetic acid-induced writhing response, and pentobarbital-induced sleeping time. EACP at a dose of 40 mg/kg significantly exhibited anti-inflammatory activities on acetic acid-induced vascular permeability, arachidonic acid-induced paw edema, and the late phase of formalin-induced licking time. Moreover, it showed anti-nociceptive effects on acetic acid-induced writhing responses and significant sedative effects on pentobarbital-induced sleeping time. The results demonstrated that the anti-nociceptive effects are apparently related to the sedative effects of EACP. These results support the use of Cynanchum paniculatum in relieving inflammatory pain.