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Parathyroid Hormone-Related Protein Production by Breast Cancers, Improved Survival, and Reduced Bone Metastases

2001; Oxford University Press; Volume: 93; Issue: 3 Linguagem: Inglês

10.1093/jnci/93.3.234

1460-2105

Michael A. Henderson, J. A. Danks, Jane M. Moseley, Joanne Slavin, T. L. Harris, M. R. McKinlay, John L. Hopper, T. John Martin,

Cancer Diagnosis and Treatment

The currentstudy investigated the relationshipamong detection of PTHrP in primarybreast cancers, development of skeletalcomplications, and overall survival.From December 1, 1989, through De-cember 31, 1994, a total of 402 consec-utively accrued women with operable(stages 1–3) invasive primary breastcancer were followed prospectively fora median period of 67 months (range,3–120 months). Impalpable tumors de-tected by screening mammography ac-counted for 5% of the cancers. Patientswith previous malignancy or preopera-tive therapy before open biopsy wereexcluded (35 patients). The timing andsite of metastases and overall survivalwere recorded, as were routine prognos-tic factors. Patients were examined atleast twice a year for 3 years and thenannually. The study was approved bythe Human Research Ethics Committeeof St. Vincent’s Hospital (Fitzroy, Aus-tralia), and patients provided informedconsent according to institutional guide-lines.There were 367 eligible patients, andthe median age at diagnosis was 60years (range, 27–92 years). The majorityof these patients were postmenopausal(70%), the median tumor size was 26mm (range, 4–180 mm), and most pa-tients were axillary lymph node negative(60%) (Table 1). PTHrP was detected byimmunohistochemistry in 265 (72%) ofthe primary breast tumors and was asso-ciated with estrogen receptor (ER) status(odds ratio [OR] 2.4; 95% confidenceinterval [CI] 1.4 to 4.0;