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Inhibitory effect of erythromycin on interleukin‐8 secretion from exudative cells in the nasal discharge of patients with chronic sinusitis

1999; Wiley; Volume: 109; Issue: 3 Linguagem: Inglês

10.1097/00005537-199903000-00012

1531-4995

Hideaki Suzuki, Yukinori Asada, Katsuhisa Ikeda, Takeshi Oshima, Tomonori Takasaka,

Sinusitis and nasal conditions

Abstract Objectives : The mechanism of the efficacy of long‐term low‐dose macrolide therapy for chronic sinusitis is not fully understood. The authors studied the inhibitory effect of erythromycin on interleukin‐8 (IL‐8) secretion from exudative cells in the nasal discharge of patients with chronic sinusitis. Study Design and Methods : Exudative cells in the nasal discharge were isolated from six patients with nonallergic chronic sinusitis. The cells, more than 90% of which were neutrophils, were incubated with or without erythromycin in the presence of 10 μg/mL of lipopolysaccharide. The IL‐8 concentrations in the culture supernatants were measured by enzyme‐linked immunoassay. Results : The amount of secreted EL‐8 in the absence of erythromycin was 682 ± 226 pg/10 6 cells/24 h. The IL‐8 secretion was significantly reduced to 66 ± 15% and 46 ± 13% of the control in the presence of 10 −6 and 10 −5 M of erythromycin, respectively. Conclusion : Erythromycin may act as a biologic modulator that inhibits IL‐8 secretion from exudative cells and thereby blocks the vicious circle of neutrophil recruitment and IL‐8 generation in the inflammatory site in chronic sinusitis.