Long-lasting remission of Behcet's disease after chlorambucil therapy.
1973; BMJ; Volume: 57; Issue: 9 Linguagem: Inglês
10.1136/bjo.57.9.706
ISSN1468-2079
Autores Tópico(s)Infectious Diseases and Tuberculosis
ResumoBeh §et (I937) drew attention to a syndrome characterized by a triad of symptoms: iritis, aphthous ulceration of the mouth, and ulcerationofthegenitalia.Although this diseasewas originally considered to be a rarity, recent reports show that it is more common and widespread than was previously thought, especially in the Middle East, the Mediterranean countries, and Japan.During the last few years, 26 patients seen in the departments of rheumatology, ophthalmology, dermatology, and neurology in our university hospital (Abdel-Fattah, Abdallah, and Fadly, I969) reflect the relatively high incidence of the disease in Egypt.The manifestations of Behget's disease are more complex and protean than the triad of symptoms originally described.Involvement of almost every system has been demon- strated; among these may be mentioned the central nervous system, the joints, the heart, the spleen, the lymph nodes, and the testes (Schotland, Wolf, White, and Dubin, I963; Nazzaro, I966; Masheter, 1959; Evans, Pallis, and Spillane, I957).Arthritis, recurrent thrombophlebitis, and erythema nodosum are now recognized as manifestations of this disease, while eye involvement is considered to be its most serious complication, since blindness is almost inevitable (Mamo and Azzam, I970).Involvement of the major arteries, such as the thoracic and abdominal aorta, was described by Hills (I967).Obli- terative endarteritis of the vasa vasorum of the main arteries, together with microaneurysms F
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