Portal de Periódicos da CAPES

The Blood Exposome and Its Role in Discovering Causes of Disease

2014; National Institute of Environmental Health Sciences; Volume: 122; Issue: 8 Linguagem: Inglês

10.1289/ehp.1308015

1552-9924

Stephen M. Rappaport, Dinesh Kumar Barupal, David S. Wishart, Paolo Vineis, Augustin Scalbert,

Nutritional Studies and Diet

Since 2001, researchers have examined the human genome (G) mainly to discover causes of disease, despite evidence that G explains relatively little risk. We posit that unexplained disease risks are caused by the exposome (E; representing all exposures) and G × E interactions. Thus, etiologic research has been hampered by scientists' continuing reliance on low-tech methods to characterize E compared with high-tech omics for characterizing G.