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Producing xylan/Eudragit® S100-based microparticles by chemical and physico-mechanical approaches as carriers for 5-aminosalicylic acid

2013; Taylor & Francis; Volume: 30; Issue: 8 Linguagem: Inglês

10.3109/02652048.2013.788087

1464-5246

Acarília Eduardo Silva, Elquio Eleamen Oliveira, Monique Christine Salgado Gomes, Henrique Rodrigues Marcelino, Karen C. Holanda Silva, Bartolomeu Santos Souza, Toshiyuki Nagashima, Alejandro Pedro Ayala, Anselmo Gomes de Oliveira, Eryvaldo Sócrates Tabosa do Egito,

Nanocomposite Films for Food Packaging

Xylan is a biopolymer found in a variety of cell wall plants. Eudragit® S-100 (ES100), a pH-dependent polymer, is used as a coating material in gastroresistant delivery systems. In this study, microparticles based on both polymers were produced by interfacial cross-linking polymerisation and/or spray-drying technique in order to investigate feasibility and stability of the systems. Size and morphology of the microparticles were characterised by optical and SEM while FT-IR, thermal analysis (TG/DTA), and X-ray diffraction (XRD) evaluated the drug–polymer interactions and the thermal behaviour of the systems. FT-IR confirmed the absence of chemical interaction between the polymers. TG/DTA analysis showed a higher stability for spray-dried microparticles and XRD data proved the amorphous feature of both carriers. The results reveal that xylan/ES100 microparticles can be produced by chemical or physico-mechanical ways, the latter being the best option due to the lack of toxic cross-linking agents and easy scale-up.