Thermal analysis of pharmaceutical compounds. V. The use of differential scanning calorimetry in the analysis of certain pharmaceuticals
1983; Elsevier BV; Volume: 61; Issue: 3 Linguagem: Inglês
10.1016/0040-6031(83)80280-9
ISSN1872-762X
Autores Tópico(s)Thermal and Kinetic Analysis
ResumoDifferential scanning calorimetric (DSC) analysis was carried out for some interesting pharmaceutical compounds which have different thermal characteristics. The compounds investigated were phenacetin, cholesterol myristate, sulphathiazole, sulphadiazine, sulphadimethyloxazole, sulphamerazine and sulphadimidine. The DSC scans of the compounds were thoroughly studied and the pronounced features for each are given, including their behaviour on fusion. It is confirmed that some of the examined pharmaceuticals, such as sulphathiazole. sulphadiazine and sulphadimethyloxazole, exist in polymorphic forms. The information obtained is useful in interpreting the results of the examination of the compounds by thermogravimetry (TG), derivative thermogravimetry (DTG), differential thermal analysis (DTA) and their melting point determinations using the Kofler microscope. The heat of reaction is calculated for all the reactions of the compounds studied. The possibility of purity determination of the examined compounds by a thermoanalytical method was studied. The DSC method was found to be suitable for the purity determination of sulphamerazine and sulphadimidine in addition to phenacetin for which the method is known to be applicable. The remaining compounds, on the other hand, do not exhibit the required characteristics for the determination of purity by the DSC method. DSC was also found to contribute to stability studies, where sulphathiazole was found to be the least stable among the examined sulphonamides.
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