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The Effect of Green Tea on Simvastatin Tolerability

2008; American College of Physicians; Volume: 149; Issue: 4 Linguagem: Inglês

10.7326/0003-4819-149-4-200808190-00019

1539-3704

José Pablo Werba, M. Giroli, Viviana Cavalca, Maria Cristina Nava, Elena Tremoli, Lorenzo Dal Bo,

Computational Drug Discovery Methods

Letters19 August 2008The Effect of Green Tea on Simvastatin TolerabilityJosé Pablo Werba, MD, Monica Giroli, PhD, Viviana Cavalca, PhD, Maria Cristina Nava, MD, PhD, Elena Tremoli, PhD, and Lorenzo Dal Bo, PhDJosé Pablo Werba, MDFrom Cardiologico Monzino Center, Istituto Di Ricovero e Cura a Carattere Scientifico, Milan 20138, Italy, and Institute for Pharmacokinetic and Analytical Studies, Ligornetto 6853, Switzerland., Monica Giroli, PhDFrom Cardiologico Monzino Center, Istituto Di Ricovero e Cura a Carattere Scientifico, Milan 20138, Italy, and Institute for Pharmacokinetic and Analytical Studies, Ligornetto 6853, Switzerland., Viviana Cavalca, PhDFrom Cardiologico Monzino Center, Istituto Di Ricovero e Cura a Carattere Scientifico, Milan 20138, Italy, and Institute for Pharmacokinetic and Analytical Studies, Ligornetto 6853, Switzerland., Maria Cristina Nava, MD, PhDFrom Cardiologico Monzino Center, Istituto Di Ricovero e Cura a Carattere Scientifico, Milan 20138, Italy, and Institute for Pharmacokinetic and Analytical Studies, Ligornetto 6853, Switzerland., Elena Tremoli, PhDFrom Cardiologico Monzino Center, Istituto Di Ricovero e Cura a Carattere Scientifico, Milan 20138, Italy, and Institute for Pharmacokinetic and Analytical Studies, Ligornetto 6853, Switzerland., and Lorenzo Dal Bo, PhDFrom Cardiologico Monzino Center, Istituto Di Ricovero e Cura a Carattere Scientifico, Milan 20138, Italy, and Institute for Pharmacokinetic and Analytical Studies, Ligornetto 6853, Switzerland.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-149-4-200808190-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Background: Many patients taking statins report muscle pain, which affects the patients' quality of life and adherence to treatment. Muscle effects of statins may be induced by interaction not only with other drugs but also with components of particular foods, such as grapefruit juice, which augment statin bioavailability (1).Objective: To report a case of statin muscle intolerance that was probably triggered by consumption of green tea.Case Report: A 61-year-old man had a history of primary hypercholesterolemia identified at age 50 years, and treatment with different statins was unsuccessful because of early muscle intolerance. He reported a family history ...References1. Lilja JJ, Neuvonen M, Neuvonen PJ. Effects of regular consumption of grapefruit juice on the pharmacokinetics of simvastatin. Br J Clin Pharmacol. 2004;58:56-60. [PMID: 15206993] CrossrefMedlineGoogle Scholar2. Donovan JL, Chavin KD, Devane CL, Taylor RM, Wang JS, Ruan Y, et al. Green tea (Camellia sinensis) extract does not alter cytochrome p450 3A4 or 2D6 activity in healthy volunteers. Drug Metab Dispos. 2004;32:906-8. [PMID: 15319329] CrossrefMedlineGoogle Scholar3. Chow HH, Hakim IA, Vining DR, Crowell JA, Cordova CA, Chew WM, et al. Effects of repeated green tea catechin administration on human cytochrome P450 activity. Cancer Epidemiol Biomarkers Prev. 2006;15:2473-6. [PMID: 17164372] CrossrefMedlineGoogle Scholar4. Kuriyama S, Shimazu T, Ohmori K, Kikuchi N, Nakaya N, Nishino Y, et al. Green tea consumption and mortality due to cardiovascular disease, cancer, and all causes in Japan: the Ohsaki study. JAMA. 2006;296:1255-65. [PMID: 16968850] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Cardiologico Monzino Center, Istituto Di Ricovero e Cura a Carattere Scientifico, Milan 20138, Italy, and Institute for Pharmacokinetic and Analytical Studies, Ligornetto 6853, Switzerland.Disclosures: None disclosed. 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