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Transcriptional activation of CCN1 and CCN2, targets of canonical Wnt signal, by ascorbic acid 2-phosphate in human dermal papilla cells

2007; Elsevier BV; Volume: 49; Issue: 3 Linguagem: Inglês

10.1016/j.jdermsci.2007.09.005

1873-569X

Young Kwan Sung, Mi Hee Kwack, Soon Re Kim, Moon Kyu Kim, Jung Chul Kim,

Wnt/β-catenin signaling in development and cancer

The mammalian hair follicle is highly organized, multi-layered, and dynamic organ. It contains dermal papilla and dermal sheath cells derived from the mesenchyme. It also contains epithelial cells of outer and inner root sheaths, matrix, and hair shaft, derived from the epithelium. The reciprocal interactions between the epithelium and mesenchyme are essential for post-natal hair growth as well as embryonic formation of hair follicle [ 1 Botchkarev V.A. Kishimoto J. Molecular control of epithelial–mesenchymal interactions during hair follicle cycling. J Investig Dermatol Symp Proc. 2003; 8: 46-55 Abstract Full Text Full Text PDF PubMed Scopus (231) Google Scholar , 2 Stenn K.S. Paus R. Controls of hair follicle cycling. Physiol Rev. 2001; 81: 449-494 Crossref PubMed Scopus (1096) Google Scholar ]. The post-natal hair follicle undergoes a cycle of anagen (the active growth phase), catagen (the apoptotic regression phase), and telogen (the resting phase) [ 1 Botchkarev V.A. Kishimoto J. Molecular control of epithelial–mesenchymal interactions during hair follicle cycling. J Investig Dermatol Symp Proc. 2003; 8: 46-55 Abstract Full Text Full Text PDF PubMed Scopus (231) Google Scholar , 2 Stenn K.S. Paus R. Controls of hair follicle cycling. Physiol Rev. 2001; 81: 449-494 Crossref PubMed Scopus (1096) Google Scholar ]. Dermal papilla (DP), a cluster of specialized fibroblasts, is believed to secret diffusible proteins which regulate the growth and activity of the various cells in the follicle, thereby plays a key role in the regulation of hair cycling and growth [ 1 Botchkarev V.A. Kishimoto J. Molecular control of epithelial–mesenchymal interactions during hair follicle cycling. J Investig Dermatol Symp Proc. 2003; 8: 46-55 Abstract Full Text Full Text PDF PubMed Scopus (231) Google Scholar , 2 Stenn K.S. Paus R. Controls of hair follicle cycling. Physiol Rev. 2001; 81: 449-494 Crossref PubMed Scopus (1096) Google Scholar ].