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Maintenance Therapy of Chronic Psychotic Patients with a Weekly Oral Dose of R16 341. A Controlled Double‐Blind Study

1970; Wiley; Volume: 10; Issue: 5 Linguagem: Inglês

10.1177/009127007001000507

2375-0839

F. Baro, J Brugmans, René Dom, Renaat Van Lommel,

Bipolar Disorder and Treatment

The Journal of Clinical Pharmacology and The Journal of New DrugsVolume 10, Issue 5 p. 330-341 Maintenance Therapy of Chronic Psychotic Patients with a Weekly Oral Dose of R16 341. A Controlled Double-Blind Study Dr. Franz Baro M.D., Dr. Franz Baro M.D. Psychiatric Clinic of the University of Louvain, BelgiumSearch for more papers by this authorDr. Jo Brugmans M.D., Corresponding Author Dr. Jo Brugmans M.D. Department of Clinical Pharmacology of Janssen Pharmaceutica, Beerse, BelgiumJanssen Pharmaceutica, Research Laboratoria, B-2340 Beerse, Belgium.Search for more papers by this authorDr. Rene Dom M.D., Dr. Rene Dom M.D. Psychiatric Clinic of the University of Louvain, BelgiumSearch for more papers by this authorRenaat Van Lommel B.Sc., Renaat Van Lommel B.Sc. Department of Clinical Pharmacology of Janssen Pharmaceutica, Beerse, BelgiumSearch for more papers by this author Dr. Franz Baro M.D., Dr. Franz Baro M.D. Psychiatric Clinic of the University of Louvain, BelgiumSearch for more papers by this authorDr. Jo Brugmans M.D., Corresponding Author Dr. Jo Brugmans M.D. Department of Clinical Pharmacology of Janssen Pharmaceutica, Beerse, BelgiumJanssen Pharmaceutica, Research Laboratoria, B-2340 Beerse, Belgium.Search for more papers by this authorDr. Rene Dom M.D., Dr. Rene Dom M.D. Psychiatric Clinic of the University of Louvain, BelgiumSearch for more papers by this authorRenaat Van Lommel B.Sc., Renaat Van Lommel B.Sc. Department of Clinical Pharmacology of Janssen Pharmaceutica, Beerse, BelgiumSearch for more papers by this author First published: September‐October 1970 https://doi.org/10.1177/009127007001000507Citations: 20AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1 Janssen, P. A. J., Niemegeers, C. J. E., Schellekens, K. H. L., Lenaerts, F. M., Verbruggen, F. J., Van Nueten, J. M., and Schaper, W. K. A.: The pharmacology of R 16 341, a new potent and orally long-acting neuroleptic drug. Europ. J. Pharmacol. in press, 1970. 2 Janssen, P. A. J., Niemegeers, C. J. E., Schellekens, K. H. L., et al.: Pimozide, a chemically novel, highly potent and orally long-acting neuroleptic drug. Arzneimittel-Forsch. 18: 261 (1968). 3 Janssen, P. A. J., Niemegeers, C. J. E., Schellekens, K. H. L., Lenaerts, F. M., Verbruggen, F. J., Van Nueten, J., Marsboom, R. H. M., Hérin, V. V., and Schaper, W. K. A.: The pharmacology of fluspirilene (R 6218), a potent, long-acting and injectable neuroleptic drug. Arzneim.-Forsch. in press, 1970. 4 Niemegeers, C. J. E.: The predictive value of the anti-apomorphine test in dogs for neuroleptic therapy in man. To be presented at the 7th Congress of the Collegium Internationale Neuro-Psychopharmacologicum, Prague, Czechoslovakia, August 1115, 1970. 5 de Smedt, R., Rodrigus, E., Debandt, R., and Brugmans, J.: Dexbenzetimide in neuroleptic-induced parkinsonism. A double-blind crossover study with a 16-week follow-up. J. Clin. Pharmacol. 10: 207 (1970). 6 Overall, J. E.: Standard psychiatric symptom description: the Factor Construct Rating Scale (FCRS). Sandoz J. Med. Sci. 8: 178 (1968). 7 Sterkmans, P., Brugmans, J., and Gevers, F.: The clinical efficacy of pimozide in chronic psychotic patients. Clin. Trials J. 5: 1107 (1968). 8 Sterkmans, P., Brugmans, J., and Gevers, F.: Clinical evaluation of fluspirilene (R 6218). A long-acting injectable neuroleptic. Clin. Trials J. 6: 19 (1969). 9 Haase, H. J.: Extrapyramidal Modification of Fine Movement. A "Conditio Sine Qua Non" of the Fundamental Therapeutic Action of Neuroleptic Drugs. In Extrapyramidal System and Neuroleptics, ed. by J. M. Bordeleau Montréal, Ed. Psychiatriques, 1961, p. 329. 10 Lehmann, H. E., and Csank, J.: Differential screening of psychotropic agents in man: psychophysiologic test data. J. Clin. Exp. Psychopath. 3: 225 (1967). 11 Knopp, W.: Exploration in the assessment and meaning of the subclinical extrapyramidal effect of neuroleptic drugs. Neuropsychopharmacol. 1: 54 (1968). Citing Literature Volume10, Issue5September‐October 1970Pages 330-341 ReferencesRelatedInformation