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BIBTEX RIS

Reversible Posterior Encephalopathy Syndrome Secondary to Sunitinib

2014; Hindawi Publishing Corporation; Volume: 2014; Linguagem: Inglês

10.1155/2014/952624

2090-6714

Ricardo Costa, Rubens Costa, Rogerio de Souza Costa, Gilberto Moura de Brito, Henrique Cartaxo, Alex Caetano de Barros,

Tuberous Sclerosis Complex Research

Reversible posterior leukoencephalopathy syndrome (RPLS) is clinical radiologic condition associated with neurological symptoms and cerebral white matter edema. It has been associated with uncontrolled hypertension, eclampsia, immunosuppressants, and more recently the use of antiangiogenic drugs. Sunitinib is an inhibitor of the vascular endothelial growth factor receptor widely used in the treatment of metastatic renal cell carcinoma (RCC). We report a rare case of RPLS occurring on therapy with sunitinib in a patient with RCC. Our aim is to highlight the importance of considering RPLS as a diagnostic possibility and to hold sunitinib for RCC patients presenting with neurologic symptoms.