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Drug/Dye‐Loaded, Multifunctional Iron Oxide Nanoparticles for Combined Targeted Cancer Therapy and Dual Optical/Magnetic Resonance Imaging

2009; Wiley; Volume: 5; Issue: 16 Linguagem: Inglês

10.1002/smll.200900389

1613-6829

Santimukul Santra, Charalambos Kaittanis, Jan Grimm, J. Manuel Perez,

Characterization and Applications of Magnetic Nanoparticles

A biocompatible, multimodal, and theranostic functional iron oxide nanoparticle is synthesized using a novel water-based method and exerts excellent properties for targeted cancer therapy, and optical and magnetic resonance imaging. For the first time, a facile, modified solvent diffusion method is used for the co-encapsulation of both an anticancer drug and near-infrared dyes. The resulting folate-derivatized theranostics nanoparticles could allow for targeted optical/magnetic resonance imaging and targeted killing of folate-expressing cancer cells.