Dermatan sulphate in haemodialysis
1992; Elsevier BV; Volume: 339; Issue: 8789 Linguagem: Inglês
10.1016/0140-6736(92)91650-w
ISSN1474-547X
AutoresDavid A. Lane, K E Ryan, H. Ireland, J. Randall Curtis, Michael T. Nurmohamed, R. T. Krediet, J W ten Cate, M.C. Roggekamp, P Stevens,
Tópico(s)Protease and Inhibitor Mechanisms
ResumoAbstract Experimental work suggests that dermatan sulphate has potential as an antithrombotic agent: it can inhibit venous thrombi yet has less effect upon bleeding than heparin. While heparin functions as an anticoagulant primarily by its ability to accelerate the action of the plasma protein inhibitor antithrombin III, dermatan sulphate acts selectively through a structurally related inhibitor, heparin co-factor II, to inhibit thrombin. We have done a series of dose-finding studies of the use of dermatan sulphate as an anticoagulant/antithrombotic agent in patients on maintenance haemodialysis. Dermatan sulphate proved to be an effective anticoagulant in this setting.
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