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The Mx GTPase family of interferon-induced antiviral proteins

2007; Elsevier BV; Volume: 9; Issue: 14-15 Linguagem: Inglês

10.1016/j.micinf.2007.09.010

1769-714X

Otto Haller, Silke Stertz, Georg Kochs,

RNA regulation and disease

Mx proteins are interferon-induced members of the dynamin superfamily of large GTPases. They inhibit a wide range of viruses by blocking an early stage of the replication cycle. Studies in genetically defined mouse strains highlight their powerful action in early antiviral host defence.