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Bromide Space Studies in Infants of Low Birth Weight

1970; Springer Nature; Volume: 4; Issue: 1 Linguagem: Inglês

10.1203/00006450-197001000-00002

1530-0447

George Cassady,

Neonatal Respiratory Health Research

Extract: The present study reports measurements of the corrected bromide space (CBS) in 74 neonates delivered vaginally and studied within 24 h of birth. The results in 37 normally grown (NG) infants ranging in birth weight from 960 to 3,450 g with gestational intervals of 27–43 weeks are contrasted with findings in 37 intrauterine growth-related infants (IGR) ranging from 1,000 to 2,460 g in birth weight with gestational intervals of 35–44 weeks. Although a direct relation exists between CBS (liters) and a varicty of variables of fetal maturity in both NG and IGR infants, the CBS in both groups would appear best related to birth weight. The corrected bromide space of IGR was virtually identical with that of their weith peers, there being no significant difference in the regression for CBS versus birth weight in the two groups. Log-log plot of this relation yields a correlation coefficient (r) of 0.98, and may be expressed as: log CBS (liters) = 0.92 × log wt (kg) - 0.371 Closer inspection of this relation revealed that an unequal distribution, with preponderance of values below the regression line at higher birth weights, was apparent. That 'tail off' suggested a curvilinear relation of CBS with increasing birth weitht, and was even more apparent when the CBS data were expressed as percentage of bedy weight (m1/kg). The mean CBS/kg in NG prematures (424±SE 7.5 m1/kg) was clearly higher (p <0.001) than in mature study infants (376±SE 8.4 m1/kg). Likewise, the average CBS/kg in the mature IGR (419±SE 11.3 m1/kg) was significantly higher (p <0.025) than the mean for the NG infants (376±SE 8.4 m1/kg). Conparison of data from NG and IGR infants revealed that 3 of 10 premature infants and 10 of 27 mature IGR infants have a CBS/kg more than 2 SD above the mean in NG infants; a CBS in excess of 476 m1/kg was observed in 11 study infants, all but 1 of whom were IGR. Speculation: Characteristically, expansion of body water compartments accompanies postnatal malnutrition. In intrauterine growth retardation, similar changes in body fluid compartments suggest an etiologic role for 'fetal malnutrition' in the disorder.