A new synthesis of aryl hetaryl ketones via S RN 1 reactions of halogenated heterocycles with potassiophenylacetonitrile followed by phase‐transfer catalyzed decyanation
1987; Wiley; Volume: 24; Issue: 4 Linguagem: Inglês
10.1002/jhet.5570240429
ISSN1943-5193
AutoresChristine K. F. Hermann, Y. P. SACHDEVA, James F. Wolfe,
Tópico(s)Catalytic C–H Functionalization Methods
ResumoAbstract Reaction of halogenated pyridines, quinolines, pyrimidines, and pyrazines with potassiophenylacetonitrile ( 5 ) in liquid ammonia under near‐uv irradiation affords secondary nitriles, which then undergo oxidative decyanation under phase‐transfer catalytic conditions to afford aryl hetaryl ketones in excellent yields.
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