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Gamma-camera renography using 123 I-Hippuran

1973; Wiley; Volume: 46; Issue: 544 Linguagem: Inglês

10.1259/0007-1285-46-544-289

1748-880X

Michael D. Short, H. I. Glass, G. D. CHISHOLM, Peter Vernon, David J. Silvester,

Renal and Vascular Pathologies

Renography has been performed with 123I-Hippuran and 123I-albuminusing a gamma camera and a digital data logging system. The methods of preparation of the 123I-labelled compounds, and the estimated absorbed dose to the kidneys and bladder, are presented. 123I-albumin was not found to be useful in predicting the count-rate in the kidney regions due to radioactivity in non-renal tissue when 123I-Hippuran is used for renography. The clearance of radioactivity from region above the level of the kidneys within the field of view of the camera provides a clinically useful measure of total effective renal plasma flow. An exact delineation of the kidneys does not appear to provide a more accurate estimate of individual effective renal plasma flow, even in the case of poorly functioning kidney. An index of tubular transit time has been obtained by observing the appearance of the radioactivity in the cortical and medullary regions in five patients, three of whom were renal transplant cases.