Estrogen receptor‐alpha (ER‐α) suppresses expression of its variant ER‐α36
2009; Wiley; Volume: 583; Issue: 8 Linguagem: Inglês
10.1016/j.febslet.2009.03.047
ISSN1873-3468
AutoresYi Zou, Ling Ding, Megan Coleman, Zhaoyi Wang,
Tópico(s)RNA Research and Splicing
ResumoRecently, we identified and cloned a membrane‐based estrogen receptor (ER), ER‐α36, which is transcribed from a previously unidentified promoter in the first intron of the original ER‐α gene. We cloned the 5′ flanking region of ER‐α36 and found the cloned DNA sequence possessed strong promoter activity. A single transcription initiation site was mapped and a number of putative regulatory elements for various transcription factors such as the Wilms’ tumor suppressor, WT1 and estrogen receptor (ER) were identified in this region. Transient co‐transfection experiments further demonstrated that ER‐α suppresses ER‐α36 promoter activity in an estrogen‐independent manner, which can be released by ER‐α36 itself.
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