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Association Between an Eestrogen Receptor Alpha Gene Polymorphism and the Risk of Prostate Cancer in Black Men

2006; Lippincott Williams & Wilkins; Volume: 175; Issue: 2 Linguagem: Inglês

10.1016/s0022-5347(05)00240-5

1527-3792

Javier Castro‐Hernández, Ivana Balic, Teresa L. Johnson‐Pais, Betsy Higgins, Kathleen C. Torkko, Ian M. Thompson, Robin J. Leach,

Prostate Cancer Treatment and Research

No AccessJournal of UrologyAdult urology1 Feb 2006Association Between an Eestrogen Receptor Alpha Gene Polymorphism and the Risk of Prostate Cancer in Black Men Javier Hernández, Ivana Balic, Teresa L. Johnson-Pais, Betsy A. Higgins, Kathleen C. Torkko, Ian M. Thompson, and Robin J. Leach Javier HernándezJavier Hernández Department of Urology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas , Ivana BalicIvana Balic Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas , Teresa L. Johnson-PaisTeresa L. Johnson-Pais Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas Department of Pediatrics, The University of Texas Health Science Center at San Antonio, San Antonio, Texas , Betsy A. HigginsBetsy A. Higgins Department of Urology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas , Kathleen C. TorkkoKathleen C. Torkko Departments of Pathology and Preventive Medicine and Biometrics, University of Colorado at Denver and Health Sciences Center, Aurora, Colorado , Ian M. ThompsonIan M. Thompson Department of Urology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas , and Robin J. LeachRobin J. Leach Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas Department of Pediatrics, The University of Texas Health Science Center at San Antonio, San Antonio, Texas View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)00240-5AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Studies suggest that SNPs within ESR1 may be associated with an increased risk of prostate cancer. We evaluated the association of the XbaI and PvuII ESR1 SNPs and prostate cancer risk in 3 different racial/ethnic populations. Materials and Methods: A total of 1,603 volunteers from the SABOR study (285 black, 876 white and 442 Hispanic men) were genotyped to assess allelic frequencies of the ESR1 SNPs. Case-control analysis was performed on 598 prostate cancer cases and 1,098 controls (260 black men, 1,013 non-Hispanic white men and 423 Hispanic white men) to assess the association between these polymorphisms and prostate cancer risk. Results: Allelic frequency was significantly different across ethnic/racial groups for both SNPs. Logistic regression analysis adjusted for age and stratified by race and ethnicity demonstrated an association between the AG genotype or presence of the G allele (GG or AG genotype) in the XbaI SNP and prostate cancer risk within black men (OR 2.25, 95% CI 1.07–4.70, p = 0.031; OR 2.14, 95% CI 1.05–4.35, p = 0.035, respectively). No association was observed among Hispanic and non-Hispanic white men for this SNP. Furthermore, there was no association between the PvuII SNP and prostate cancer risk across all groups. 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Google Scholar 19 : Association of African-American ethnic background with survival in men with metastatic prostate cancer. J Natl Cancer Inst2001; 93: 219. Crossref, Medline, Google Scholar © 2006 by American Urological AssociationFiguresReferencesRelatedDetails Volume 175Issue 2February 2006Page: 523-527 Advertisement Copyright & Permissions© 2006 by American Urological AssociationKeywordsprostatic neoplasmsAcknowledgmentsAll study subjects in SABOR and the prevalence case study are acknowledged. The SABOR clinical staff provided skilled assistance.MetricsAuthor Information Javier Hernández Department of Urology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas Nothing to disclose. More articles by this author Ivana Balic Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas Nothing to disclose. More articles by this author Teresa L. Johnson-Pais Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas Department of Pediatrics, The University of Texas Health Science Center at San Antonio, San Antonio, Texas Nothing to disclose. More articles by this author Betsy A. Higgins Department of Urology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas Nothing to disclose. More articles by this author Kathleen C. Torkko Departments of Pathology and Preventive Medicine and Biometrics, University of Colorado at Denver and Health Sciences Center, Aurora, Colorado Nothing to disclose. More articles by this author Ian M. Thompson Department of Urology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas Financial interest and/or other relationship with Mission Pharmacal, Predicant, Threshold Pharmaceuticals, Abbott Pharmaceuticals, National Cancer Institute and AstraZeneca. More articles by this author Robin J. Leach Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas Department of Pediatrics, The University of Texas Health Science Center at San Antonio, San Antonio, Texas Nothing to disclose. More articles by this author Expand All Advertisement PDF downloadLoading ...