Supercooling enables long-term transplantation survival following 4 days of liver preservation
2014; Nature Portfolio; Volume: 20; Issue: 7 Linguagem: Inglês
10.1038/nm.3588
ISSN1546-170X
AutoresTim Berendsen, Bote G. Bruinsma, Catheleyne F. Puts, Nima Saeidi, O. Berk Usta, Basak E. Uygun, Maria‐Louisa Izamis, Mehmet Toner, Martin L. Yarmush, Korkut Uygun,
Tópico(s)Liver Disease and Transplantation
ResumoTim Berendsen and colleagues describe an approach for long-term liver preservation based on cryopreservation, supercooling and machine perfusion where rat livers preserved for 4 d remain viable following transplantation. The realization of long-term human organ preservation will have groundbreaking effects on the current practice of transplantation. Herein we present a new technique based on subzero nonfreezing preservation and extracorporeal machine perfusion that allows transplantation of rat livers preserved for up to four days, thereby tripling the viable preservation duration.
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