Microanatomical localization of PD-1 in human tonsils
2002; Elsevier BV; Volume: 83; Issue: 3 Linguagem: Inglês
10.1016/s0165-2478(02)00088-3
ISSN1879-0542
AutoresYoshiko Iwai, Taku Okazaki, Hiroyuki Nishimura, Akemi Koyanagi, Hideo Yagita∥, Tasuku Honjo,
Tópico(s)Immunotherapy and Immune Responses
ResumoPD-1 is an immunoinhibitory receptor, which belongs structurally to the CD28 family. PD-1-deficient mice show breakdown of peripheral tolerance and manifest multiple autoimmune symptoms. We previously described expression of PD-1 on activated T and B lymphocytes and myeloid cells. However, little is known about the microanatomical distribution of PD-1 in lymphoid organs. In this study, we performed immunohistochemistry using monoclonal antibodies against human PD-1. In human tonsils, PD-1 was expressed on most of T cells and a small subset of centrocytes in the light zone of germinal centers (GCs), where clonal selection of centrocytes takes place. These results suggest that PD-1 may play an important role in GC reaction.
Referência(s)