Acute effect of glycerol on net cerebrospinal fluid production in dogs
1985; American Association of Neurological Surgeons; Volume: 63; Issue: 5 Linguagem: Inglês
10.3171/jns.1985.63.5.0759
ISSN1933-0693
AutoresHuda Y. Zoghbi, Sada Okumura, John P. Laurent, Marvin A. Fishman,
Tópico(s)Liver Disease and Transplantation
ResumoThe effect of glycerol administration on cerebrospinal fluid (CSF) formation in dogs was studied by means of a ventriculocisternal perfusion technique. Net CSF production rate decreased after oral administration of glycerol (3 gm/kg) from a baseline level of 42.33 +/- 6.68 microliter/min (mean +/- standard error) to a trough of 10.33 +/- 4.88 microliter/min at 90 minutes after administration (p less than 0.025). Serum osmolality concomitantly increased from a baseline value of 296 +/- 2.83 to 309 +/- 4.7 mOsm/kg H2O at 90 minutes. The mean percentage change in CSF production inversely correlated to the mean percentage change in serum osmolality, r = -0.85. Thus, glycerol administration decreases net CSF formation, and this effect may be related in part to the rise in serum osmolality.
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