Portal de Periódicos da CAPES

Can we trigger an acute coronary syndrome?

2006; BMJ; Volume: 92; Issue: 8 Linguagem: Inglês

10.1136/hrt.2005.086652

1468-201X

Robert A. Kloner,

Injury Epidemiology and Prevention

Introduction: It is perceived that young children have difficulty inhaling with a mouthpiece. The VR647 inhalation system (VR647IS) is a breath-actuated device for paediatric patients that guides inhalation flow rate and volume to improve delivery to the lung and provides real-time feedback to improve the patient’s inhalation technique. Aims: To assess if young children could use the VR647IS with a mouthpiece. Methods: Children aged 1–4 years with cough and/or recurrent wheeze in the past year, and who had used either a MDI with a spacer or a nebulizer, were included in this open-label study. Patients inhaled isotonic saline for nebulization using VR647IS with a mouthpiece, during two clinic visits (V1/V2), 4–8 days apart. Inhalation success was assessed at the third attempt at each visit. In a human factors study use of VR647IS with a mouthpiece and a face mask was also assessed in 15 children aged 1-8 years. Results: Overall, 40/41 patients attempted at least one inhalation. Most patients used VR467IS with a mouthpiece successfully (65% and 70% at V1 and V2, respectively); 90% of patients aged 3–4 years, 64% aged 2 years and 17% aged 1 year were successful at using VR647IS with a mouthpiece at V2. Most patients (89%) aged 4 years inhaled with a mouthpiece without hands-on assistance at V2 and 43% of children aged 2 years could use it without assistance. In the human factors study 80% of all participants and 83% of children aged 1-2 years were able to use VR647IS with the mouthpiece. Conclusions: 90% of children aged > 2 years were able to use VR647IS with a mouthpiece, and 89% of children aged 4 years could use VR647IS, without assistance.