Enantiomeric separation of some piperidine-2,6-dione drugs using chiralcel OJ-R column
1997; Wiley; Volume: 9; Issue: 1 Linguagem: Inglês
10.1002/(sici)1520-636x(1997)9
ISSN1520-636X
AutoresHassan Y. Aboul‐Enein, Soliman A. Bakr,
Tópico(s)Molecular spectroscopy and chirality
ResumoA newly developed reversed phase cellulose tris(4-methyl benzoate) known as Chiralcel OJ-R was used to investigate the chiral recognition and enantiomeric separation of eight racemic piperidine-2,6-dione compounds—namely, aminoglutethimide and its major metabolite acetylaminoglutethimide, glutethimide, cyclohexylamino-glutethimide, pyridoglutethimide, thalidomide, phenglutarimide, and 3-phenylacetyl-amino-2,6-piperidinedione (antineoplaston A-10). Chiral separation of these compounds was achieved under varying ratios of the mobile phase, except for phenglutarimide and 3-phenylacetylamino-2,6-piperidinedione, for which separation was unsuccessful. Possible chiral recognition mechanisms are also presented. Chirality 9:10–12, 1997. © 1997 Wiley-Liss, Inc.
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