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Dextran protection of erythrocytes from low‐pH‐induced hemolysis

1989; Wiley; Volume: 250; Issue: 2 Linguagem: Inglês

10.1016/0014-5793(89)80741-0

1873-3468

Amelia Cudd, Tudor Arvinte, Barbara Schulz, Claude Nicolau,

Hemoglobin structure and function

Low-pH-induced hemolysis of erythrocytes is inhibited by dextrans. The protective effect was observed with dextrans larger than 40 kDa. Electron microscopy showed dextrans of 150 kDa in a tight association with the erythrocyte membrane. These results indicate that dextrans stop the low-pH-induced hemolysis by interacting with the acid-induced defects in the erythrocyte membrane [(1989) Biochim. Biophys. Acta, in press].