Prostacyclin Stimulation of the Activation of Blood Coagulation Factor X by Platelets
1986; American Association for the Advancement of Science; Volume: 231; Issue: 4736 Linguagem: Inglês
10.1126/science.3001935
ISSN1095-9203
AutoresAsim K. Duttaroy, Tarun K. Ray, Asru K. Sinha,
Tópico(s)Heparin-Induced Thrombocytopenia and Thrombosis
ResumoWhen platelets were incubated with prostacyclin, prostaglandin E1, or prostaglandin D2 at concentrations insufficient to increase the level of adenosine 3',5'-monophosphate (cyclic AMP), coagulation factor X was activated by a platelet cysteine protease. Prostacyclin or prostaglandin E1 at higher concentrations increased the cyclic AMP level and inhibited the activation of factor X by platelets. Inhibition of platelet adenylate cyclase by 2',5'-dideoxyadenosine allowed the activation of the protease at higher concentrations of the autocoids. Prostaglandins A1, A2, B1, B2, E2, F2 alpha, 6-keto-prostaglandin F1 alpha, and thromboxane B2, which do not affect platelet cyclic AMP level, did not stimulate the protease.
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