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Leg Blood Flow in Intermittent Claudication — A Comparison Between Non Insulin Dependent Diabetics and Non Diabetics

1984; SAGE Publishing; Volume: 35; Issue: 11 Linguagem: Inglês

10.1177/000331978403501106

1940-1574

Lars Janzon, Sven‐Erik Bergentz, B.F. Ericsson, Martin Hanson, Sven‐Eric Lindell,

Cardiovascular Health and Disease Prevention

The influence of diabetes on leg blood flow in intermittent claudication has been assessed by comparing the systolic arm-ankle pressure gradient at rest and resistance to blood flow during reactive hyperemia in patients with non-insulin dependent diabetes and non-diabetic controls. Cases and controls were matched for age and sex. Smoking habits, blood pressure, and blood lipids didn't differ in the two groups. Diabetes was associated with a higher resistance to blood flow during reactive hyperemia and a greater arm-ankle pressure gradient at rest. Resistance to blood flow during reactive hyperemia was in the non-diabetics strongly correlated to the arm-ankle pressure gradient at rest (r=0.84). Corres ponding correlation coefficient was in diabetics 0.04. In one of four diabetic legs a high resistance to blood flow during reactive hyperemia didn't correspond to a big arm-ankle pressure gradient. The results in this study support the concept of both macro- and microvascular disease in diabetes.