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Comparison of intravenous ketorolac with morphine for postoperative pain in children

1992; Wiley; Volume: 52; Issue: 4 Linguagem: Inglês

10.1038/clpt.1992.167

1532-6535

Eeva‐Liisa Maunuksela, Merja Kokki, Roy Bullingham,

Pain Management and Opioid Use

Clinical Pharmacology & TherapeuticsVolume 52, Issue 4 p. 436-443 Clinical Trials and Therapeutics Comparison of intravenous ketorolac with morphine for postoperative pain in children Eeva-Liisa Maunuksela MD, PhD, Corresponding Author Eeva-Liisa Maunuksela MD, PhD Department of Ophthalmology, Helsinki University Hospital, Helsinki Department of Anesthesiology, Kuopio University Hospital, Kuopio Syntex Clinical Research, MaidenheadEeva-Liisa Maunuksela MD, PhD Department of Anesthesiology, Texas Tech University Health Sciences Center, Lubbock, Texas 79430.Search for more papers by this authorHannu Kokki MD, Hannu Kokki MD Department of Ophthalmology, Helsinki University Hospital, Helsinki Department of Anesthesiology, Kuopio University Hospital, Kuopio Syntex Clinical Research, MaidenheadSearch for more papers by this authorRoy E S Bullingham MD, FFARCS, Roy E S Bullingham MD, FFARCS Department of Ophthalmology, Helsinki University Hospital, Helsinki Department of Anesthesiology, Kuopio University Hospital, Kuopio Syntex Clinical Research, MaidenheadSearch for more papers by this author Eeva-Liisa Maunuksela MD, PhD, Corresponding Author Eeva-Liisa Maunuksela MD, PhD Department of Ophthalmology, Helsinki University Hospital, Helsinki Department of Anesthesiology, Kuopio University Hospital, Kuopio Syntex Clinical Research, MaidenheadEeva-Liisa Maunuksela MD, PhD Department of Anesthesiology, Texas Tech University Health Sciences Center, Lubbock, Texas 79430.Search for more papers by this authorHannu Kokki MD, Hannu Kokki MD Department of Ophthalmology, Helsinki University Hospital, Helsinki Department of Anesthesiology, Kuopio University Hospital, Kuopio Syntex Clinical Research, MaidenheadSearch for more papers by this authorRoy E S Bullingham MD, FFARCS, Roy E S Bullingham MD, FFARCS Department of Ophthalmology, Helsinki University Hospital, Helsinki Department of Anesthesiology, Kuopio University Hospital, Kuopio Syntex Clinical Research, MaidenheadSearch for more papers by this author First published: October 1992 https://doi.org/10.1038/clpt.1992.167Citations: 14AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Abstract Ninety-two children from 3 to 12 years of age were given intravenous morphine or ketorolac by titration, or ketorolac by bolus injection for moderate or severe postsurgical pain in a double-blind randomized parallel-group study. Pain scores were assessed every 5 minutes until pain relief was complete, and then every 15 minutes for 8 hours or until pain returned. Twenty-nine of 30 patients receiving morphine and 25 of 30 patients in each group receiving ketorolac achieved pain relief. The subjects in the morphine group required statistically fewer doses for analgesia than the subjects in the ketorolac groups. The sums of pain intensity differences calculated from the start of the study numerically favored morphine, but the sum of pain intensity differences from pain relief until 50% withdrew were significantly better in the ketorolac groups. Median durations of analgesia from initial drug administration were 170, 190, and 225 minutes in the morphine, ketorolac titration, and ketorolac bolus groups, respectively. The most common side effect was injection site pain. Analgesia after intravenous ketorolac developed more slowly but was sustained better than morphine. Clinical Pharmacology and Therapeutics (1992) 52, 436–443; doi:10.1038/clpt.1992.167 Citing Literature Volume52, Issue4October 1992Pages 436-443 RelatedInformation