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Montreal Cognitive Assessment Memory Index Score (MoCA‐MIS) as a Predictor of Conversion from Mild Cognitive Impairment to A lzheimer's Disease

2014; Wiley; Volume: 62; Issue: 4 Linguagem: Inglês

10.1111/jgs.12742

1532-5415

Parunyou Julayanont, Mélanie Brousseau, Howard Chertkow, Natalie A. Phillips, Ziad Nasreddine,

Epilepsy research and treatment

Objectives To assess the usefulness of the Montreal Cognitive Assessment (Mo CA ) total score (Mo CA ‐ TS ) and Memory Index Score (Mo CA ‐ MIS ) in predicting conversion to A lzheimer's disease ( AD ) in individuals with mild cognitive impairment ( MCI ). Design Retrospective chart review. Setting Community‐based memory clinic. Participants Individuals meeting P etersen's MCI criteria (N = 165). Measurements Baseline Mo CA scores at MCI diagnosis were collected from charts of eligible individuals with MCI , and Mo CA ‐ TS , Mo CA ‐ MIS , and a cognitive domain index score were calculated to assess their prognostic value in predicting conversion to AD . Results One hundred fourteen participants progressed to AD ( MCI ‐ AD ), and 51 did not (nonconverters; MCI ‐ NC ); 90.5% of participants with MCI with a Mo CA ‐ TS less than 20/30 and a Mo CA ‐ MIS less than 7/15 at baseline converted to AD within the average follow‐up period of 18 months, compared with 52.7% of participants with MCI above the cutoffs on both scores. Individuals with multiple‐domain amnestic MCI had the highest AD conversion rates (73.9%). Conclusion Identifying individuals with MCI at high risk of conversion to AD is important clinically and for selecting appropriate subjects for therapeutic trials. Individuals with MCI with a low Mo CA ‐ TS and a low newly devised memory index score (Mo CA ‐ MIS ) are at greater risk of short‐term conversion to AD .