Portal de Periódicos da CAPES

Interferon: a cytotoxic T lymphocyte differentiation signal

1986; Wiley; Volume: 16; Issue: 7 Linguagem: Inglês

10.1002/eji.1830160709

1521-4141

Likuang Chen, Bcatrice Tourvieille, Gordon F. Burns, Fritz H. Bach, D Mathieu-Mahul, Marilyne Sasportes, Armand Bensussan,

CAR-T cell therapy research

Abstract Human T cell clones which were able to proliferate in response to specific stimuli but could not kill even in the presence of lectins were found to acquire the specific lytic function when interferon alpha or gamma was added on day 1 of the 7‐day restimulation culture. These results demonstrate that interferon may act as a cytotoxic T lymphocyte differentiation signal. This signal can be blocked by the monoclonal antibody LeoA1 which recognizes a 70‐kDa cell surface structure, involved in cytotoxic T lymphocyte differentiation.