How to measure insulin secretion

1994; Wiley; Volume: 10; Issue: 2 Linguagem: Inglês

10.1002/dmr.5610100204

ISSN

1099-0895

Autores

Roman Hovorka, R. H. Jones,

Tópico(s)

Pancreatic function and diabetes

Resumo

Diabetes/Metabolism ReviewsVolume 10, Issue 2 p. 91-117 Paper How to measure insulin secretion Roman Hovorka, Roman Hovorka Centre for Measurement and Information in Medicine, Department of Systems Science, City University, London, U.K. Department of Medicine, United Medical and Dental Schools, St. Thomas's Hospital, London SE1 7EH, U.K.Search for more papers by this authorRichard H. Jones, Corresponding Author Richard H. Jones Department of Medicine, United Medical and Dental Schools, St. Thomas's Hospital, London SE1 7EH, U.K.Department of Medicine, United Medical and Dental Schools, St. Thomas's Hospital, Lambeth Palace Road, London SE1 7EH, U.K.Search for more papers by this author Roman Hovorka, Roman Hovorka Centre for Measurement and Information in Medicine, Department of Systems Science, City University, London, U.K. Department of Medicine, United Medical and Dental Schools, St. Thomas's Hospital, London SE1 7EH, U.K.Search for more papers by this authorRichard H. Jones, Corresponding Author Richard H. Jones Department of Medicine, United Medical and Dental Schools, St. Thomas's Hospital, London SE1 7EH, U.K.Department of Medicine, United Medical and Dental Schools, St. Thomas's Hospital, Lambeth Palace Road, London SE1 7EH, U.K.Search for more papers by this author First published: July 1994 https://doi.org/10.1002/dmr.5610100204Citations: 55AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1 Groop LC, Widen E, and Ferrannini E: Insulin resistance and insulin deficiency in the pathogenesis of type 2 (non-insulin-dependent) diabetes mellitus: errors of metabolism or of methods. Diabetologia 36: 1326–1331, 1993. 2 Sonksen PH, Tompkins CV, Srivastava MC, and Nabarro JDN: A comparative study on the metabolism of human insulin and porcine proinsulin in man. Clin Sci Mol Med 45: 633–654, 1973. 3 Shapiro ET, Tillil H, Rubenstein AH, and Polonsky KS: Peripheral insulin parallels changes in insulin secretion more closely than C-peptide after bolus intravenous glucose administration. J Clin Endocrinol Metab 67: 1094–1099, 1988. 4 Ferrannini E, and Cobelli C: The kinetics of insulin in man. II. Role of the liver. Diabetes/Metab Rev 3: 365–397, 1987. 5 Ferrannini E, Wahren J, Faber OK, Felig P, Binder C, and DeFronzo RA: Splanchnic and renal metabolism of insulin in human subjects: a dose–response study. Am J Physiol 244: E517–E527, 1983. 6 Van Cauter E, Mestrez F, Sturis J, and Polonsky KS: Estimation of insulin secretion rates from C-peptide levels: comparison of individual and standard kinetic parameters for C-peptide clearance. Diabetes 41: 368–377, 1992. 7 Watanabe RM, Volund A, Roy S, and Bergman RN: Prehepatic β-cell secretion during the intravenous glucose tolerance test in humans: application of a combined model of insulin and C-peptide kinetics. J Clin Endocrinol Metab 69: 790–797, 1989. 8 Groop LC, Barzilai N, Ratheiser K, Luzi L, Wahlin Boll E, Melander A, and DeFronzo RA: Dose-dependent effects of glyburide on insulin secretion and glucose uptake in humans. Diabetes Care 14: 724–727, 1991. 9 Groop L, Luzi L, Melander A, Groop PH, Ratheiser K, Simonson DC, and DeFronzo RA: Different effects of glyburide and glipizide on insulin secretion and hepatic glucose production in normal and NIDDM subjects. Diabetes 36: 1320–1328, 1987. 10 Watanabe RM, Steil GM, and Kruszynska YT: Accurate assessments of prehepatic insulin secretion from a single protocol using a combined model with 2-compartment C-peptide kinetics (Abstract). Diabetes 42 (Suppl 1): 172A, 1993. 11 Kanatsuka A, Makino H, Sakurada M, Hashimoto N, Iwaoka H, Yamaguchi T, Taira M, Yoshida S, and Yoshida A: First-phase insulin response to glucose in nonobese or obese subjects with glucose intolerance: analysis by C-peptide secretion rate. Metab Clin Exp 37: 878–884, 1988. 12 Karam JH, Grodsky GM, and Ching KN: “Staircase” glucose stimulation of insulin secretion in obesity. Measure of beta cell sensitivity and capacity. Diabetes 23: 763–770, 1974. 13 Tillil H, Shapiro ET, Given BD, Rue P, Rubenstein AH, Galloway JA, and Polonsky KS: Reevaluation of urine C-peptide as a measure of insulin secretion. Diabetes 37: 1195–1201, 1988. 14 Bergsten P, and Hellman B: Glucose-induced amplitude regulation of pulsatile insulin secretion from individual pancreatic islets. Diabetes 42: 670–674, 1993. 15 Polonsky KS, Given BD, Hirsch LJ, Tillil H, Shapiro ET, Beebe C, Frank BH, Galloway JA, and Van Cauter E: Abnormal patterns of insulin secretion in non-insulin-dependent diabetes mellitus. N Engl J Med 318: 1231–1239, 1988. 16 Sturis J, Polonsky KS, Shapiro ET, Blackman JD, O'Meara NM, and Van Cauter E: Abnormalities in the ultradian oscillations of insulin secretion and glucose levels in type 2 (non-insulin-dependent) diabetic patients. Diabetologia 35: 681–689, 1992. 17 Sturis J, O'Meara NM, Shapiro ET, Blackman JD, Tillil H, Polonsky KS, and Van Cauter E: Differential effects of glucose stimulation upon rapid pulses and ultradian oscillations of insulin secretion. J Clin Endocrinol Metab 76: 895–901, 1993. 18 Balks HJ, Schmidt A, Prank K, Hemmer F, von zur Muhlen A, and Brabant G: Temporal pattern of pancreatic insulin and C-peptide secretion and of plasma glucose levels after nutritional stimulation. J Clin Endocrinol Metab 75: 1198–1203, 1992. 19 Bingley PJ, Matthews DR, Williams AJK, Bottazzo GF, and Gale EAM: Loss of regular oscillatory insulin secretion in islet cell antibody positive non-diabetic subjects. Diabetologia 35: 32–38, 1992. 20 Shapiro ET, Tillil H, Polonsky KS, Fang VS, Rubenstein AH, and Van Cauter E: Oscillations in insulin secretion during constant glucose infusion in normal man: relationship to changes in plasma glucose. J Clin Endocrinol Metab 67: 307–314, 1988. 21 Simon C, Brandenberger G, and Follenius M: Ultradian oscillations of plasma glucose, insulin, and C-peptide in man during continuous enteral nutrition. J Clin Endocrinol Metab 64: 669–674, 1987. 22 Polonsky KS, Given BD, and Van Cauter E: Twenty-four-hour profiles and pulsatile patterns of insulin secretion in normal and obese subjects. J Clin Invest 81: 442–448, 1988. 23 Kraegen EW, Young JD, George EP, and Lazarus L: Oscillations in blood glucose and insulin after oral glucose. Horm Metab Res 4: 409–413, 1972. 24 O'Rahilly SP, Turner RC, and Matthews DR: Impaired pulsatile secretion of insulin in relatives of patients with non-insulin-dependent diabetes. N Engl J Med 318: 1225–1230, 1988. 25 Van Cauter E, Shapiro ET, Tillil H, and Polonsky KS: Circadian modulation of glucose and insulin responses to meals; relationship to Cortisol rhythm. Am J Physiol 262: E467–E475, 1992. 26 Rubenstein AH, Clark JL, Melani F, and Steiner DF: Secretion of proinsulin C-peptide by pancreatic beta cells and its circulation in blood. Nature 224: 697–699, 1969. 27 Polonsky KS, and Rubenstein AH: Current approaches to measurement of insulin secretion. Diabetes/Metab Rev 2: 315–329, 1986. 28 Polonsky KS, Frank BH, Pugh W, Addis A, Karrison T, Meier P, Tager H, and Rubenstein AH: The limitations to and valid use of C-peptide as a marker of the secretion of insulin. Diabetes 35: 379–386, 1986. 29 Polonsky KS, and Rubeinstein AH: C-peptide as a measure of the secretion and hepatic extraction of insulin. Diabetes 33: 486–494, 1984. 30 Madsbad S, Hartling SG, and Faber OK: C-peptide and proinsulin. In International Textbook of Diabetes Mellitus, KGMM Alberti, RA DeFronzo, H Keen, and P Zimmet, Eds. John Wiley, New York, 1992, pp 303–332. 31 Faber OK, and Binder C: C-peptide: an index of insulin secretion. Diabetes/Metab Rev 2: 331–345, 1986. 32 Polonsky KS, Japan J, Emmanouel D, Holmes K, and Moossa AR: Differences in the hepatic and renal extraction of insulin and glucagon in the dog: evidence for saturability of insulin metabolism. Acta Endocrinol 102: 420–427, 1983. 33 Horwitz DL, Starr JI, Mako ME, Blackard WG, and Rubenstein AH: Proinsulin, insulin and C-peptide concentrations in human portal and peripheral blood. J Clin Invest 55: 1278–1283, 1975. 34 Polonsky KS, Pugh W, Jaspan JB, Cohen DM, Karrison T, Tager HS, and Rubenstein AH: C-peptide and insulin secretion: relationship between peripheral concentrations of C-peptide and insulin and their secretion rates in the dog. J Clin Invest 74: 1821–1829, 1984. 35 Field JB: Extraction of insulin by the liver. Annu Rev Med 20: 309–314, 1973. 36 Eaton EP, Allen RC, and Schade DS: Hepatic removal of insulin in normal man: dose response to endogenous insulin secretion. J Clin Endocrinol Metab 56: 1294–1300, 1983. 37 Hovorka R, Powrie JK, Smith GD, Sonksen PH, Carson ER, and Jones RH: Five-compartment model of insulin kinetics and its use to investigate action of chloroquine in NIDDM. Am J Physiol 265: E162–E175, 1993. 38 Tranberg KG: Hepatic uptake of insulin in man. Am J Physiol 237: E509–E518, 1979. 39 Waldhausl WK, Bratusch Marrain P, and Gasic S: Inhibition by proinsulin of endogenous C-peptide release in healthy man. Am J Physiol 251: E139–E145, 1986. 40 Jones RH, Sonksen PH, Boroujerdi MA, and Carson ER: Number and affinity of insulin receptors in intact human subjects. Diabetologia 27: 207–211, 1984. 41 Morishima T, Pye S, Bradshaw C, and Radziuk J: Posthepatic rate of appearance of insulin: measurement and validation in the nonsteady state. Am J Physiol 263: E772–E779, 1992. 42 Cobelli C, Mori A, and Ferrannini E: On linearity of insulin kinetics. Am J Physiol 251: E247–E248, 1986. 43 Polonsky KS, Licinio-Paixao J, Given BD, Pugh W, Rue P, Galloway JA, Karrison T, and Frank BH: Use of biosynthetic human C-peptide in the measurement of insulin secretion rates in normal volunteers and type I diabetic patients. J Clin Invest 77: 98–105, 1986. 44 Licinio-Paixao J, Polonsky KS, Given BD, Pugh W, Ostrega D, Frank BH, and Rubenstein AH: Ingestion of a mixed meal does not affect the metabolic clearance rate of biosynthetic human C-peptide. J Clin Endocrinol Metab 63: 401–403, 1986. 45 Wojcikowski C, Blackman JD, Ostrega D, Lewis GF, Galloway JA, Rubenstein AH, and Polonsky KS: Lack of effect of high-dose biosynthetic human C-peptide on pancreatic hormone release in normal subjects. Metabolism 39: 827–832, 1990. 46 Faber OK, Hagen C, Binder C, Markussen J, Naithani VK, Blix PM, Kuzuya H, Horwitz DL, Rubenstein AH, and Rossing N: Kinetics of human connecting peptide in normal and diabetic subjects. J Clin Invest 62: 197–203, 1978. 47 Eaton RP, Allen RC, Schade DS, Erickson KM, and Standefer J: Prehepatic insulin production in man: kinetic analysis using peripheral connecting peptide behaviour. J Clin Endocrinol Metab 51: 520–528, 1980. 48 Matthews DR, Rudenski AS, Burnett MA, Darling P, and Turner RC: The half-life of endogenous insulin and C-peptide in man assessed by somatostatin suppression. Clin Endocrinol 23: 71–79, 1985. 49 Sturis J, Van Cauter E, Blackman JD, and Polonsky KS: Entrainment of pulsatile insulin secretion by oscillatory glucose infusion. J Clin Invest 87: 439–445, 1991. 50 Van Cauter E, Blackman JD, Roland D, Spire JP, Refetoff S, and Polonsky KS: Modulation of glucose regulation and insulin secretion by circadian rhythmicity and sleep. J Clin Invest 88: 934–942, 1991. 51 De Nicolao G, and Liberati D: Linear and nonlinear techniques for the deconvolution of hormone time-series. IEEE Trans Biomed Eng 40: 440–455, 1993. 52 Press WH, Teukolsky SA, Vetterling WT, and Flannery BP: Numerical Recipes in C, 2nd ed. Cambridge University Press, Cambridge, 1992. 53 Nauck MA, Homberger E, Siegel EG, Allen RC, Eaton RP, Ebert R, and Creutzfeldt W: Incretin effects of increasing glucose loads in man calculated from venous insulin and C-peptide responses. J Clin Endocrinol Metab 63: 492–498, 1986. 54 Gumbiner B, Polonsky KS, Beltz WF, Wallace P, Brechtel G, and Fink RI: Effects of aging on insulin secretion. Diabetes 38: 1549–1556, 1989. 55 Hovorka R, Powrie JK, and Jones RH: Reconstruction of prehepatic insulin secretion during hyperinsulinaemic euglycaemic clamps (Abstract). Diabetes 40: 13A, 1991. 56 Polonsky KS, Given BD, Hirsch L, Shapiro ET, Tillil H, Beebe C, Galloway JA, Frank BH, Karrison T, and Van Cauter E: Quantitative study of insulin secretion and clearance in normal and obese subjects. J Clin Invest 81: 435–441, 1988. 57 Cleveland W: Robust locally weighted regression and smoothing scatterplots. J Am Stat Assoc 74: 829–836, 1979. 58 Sparacino G, Sturis J, O'Meara NM, Byrne M, De Nicolao G, Polonsky KS, and Cobelli C: A deconvolution method to quantify rapid pulses in insulin secretion. In Proceedings of the 15th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Szeto AYJ, and Rangayyan RM, Eds. IEEE, San Diego, 1993, pp 536–537. 59 Hovorka R: A computer program to reconstruct insulin secretion (Abstract). Diabetologia 36 (Suppl 1): A68, 1993. 60 Twomey S: The application of numerical filtering to the solution of integral equations encountered in indirect sensing measurements. J Franklin Inst 279: 95–109, 1965. 61 Perrone M, Rix H, and Bataillou E: Deconvolution methods for nonnegative signals. In Proceedings of the 15th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Szeto AYJ, and Rangayyan RM, Eds. IEEE, San Diego, 1993, pp 416–417. 62 Wahba G: Constrained regularization for ill posed linear operator equations, with applications in meteorology and medicine. In Statistical Decision Theory and Related Topics III, SS Gupta, and JO Berger, Eds. Academic Press, New York, 1982, pp 383–418. 63 Grodsky GM: A threshold distribution hypothesis for packet storage of insulin and its mathematical modeling. J Clin Invest 51: 2047–2059, 1972. 64 Cerasi E, Fick G, and Rudemo M: A mathematical model for the glucose induced insulin release in man. Eur J Clin Invest 4: 267–278, 1974. 65 Cerasi E: Differential actions of glucose on insulin release: re-evaluation of a mathematical model. In Carbohydrate Metabolism: Quantitative Physiology and Mathematical Modelling, C Cobelli, and RN Bergman, Eds. John Wiley, Chichester, 1981, pp 3–24. 66 Licko V: Modelling insulin secretion: analysis of glucose tolerance tests. In Carbohydrate Metabolism: Quantitative Physiology and Mathematical Modelling, C Cobelli, and RN Bergman, Eds. John Wiley, Chichester, 1981, pp 25–36. 67 Hagander P, Tranberg KG, Thorell J, and DiStefano JJI: Models for the insulin response to intravenous glucose. Math Biosci 42: 15–29, 1978. 68 Licko V, and Silvers A: Open-loop glucose–insulin control with threshold secretory mechanism: analysis of intravenous glucose tolerance tests in man. Math Biosci 27: 319–332, 1975. 69 Toffolo G, Bergman RN, Finegood DT, Bowden CR, and Cobelli C: Quantitative estimation of beta cell sensitivity to glucose in the intact organism. A minimal model of insulin kinetics in the dog. Diabetes 29: 979–990, 1980. 70 Ferrannini E, and Cobelli C: The kinetics of insulin in man. I. General aspects. Diabetes/Metab Rev 3: 335–363, 1987. 71 McGuire EA, Tobin JD, Berman M, and Andres R: Kinetics of native insulin in diabetic, obese and aged men. Diabetes 28: 110–120, 1979. 72 Morishima T, Bradshaw C, and Radziuk J: Measurement using tracers of steady-state turnover and metabolic clearance of insulin in dogs. Am J Physiol 248: E203–E208, 1985. 73 Marquardt DW: An algorithm for least squares estimation of nonlinear parameters. J Soc Ind Appl Math 2: 431–441, 1963. 74 Carson ER, Cobelli C, and Finkelstein L: The Mathematical Modeling of Metabolic and Endocrine Systems, John Wiley, New York, 1983. 75 Cobelli C, and Pacini G: Insulin secretion and hepatic extraction in humans by minimal modeling of C-peptide and insulin kinetics. Diabetes 37: 223–231, 1988. 76 Toffolo G, De Grandi F, and Cobelli C: Assessment of insulin secretion from minimal modeling: necessity of accurate decription of C-peptide kinetics (Abstract). Diabetologia 36 (Suppl 1): A120, 1993. 77 Volund A, Polonsky KS, and Bergman RN: Calculated pattern of intraportal insulin appearance without independent assessment of C-peptide kinetics. Diabetes 36: 1195–1202, 1987. 78 Tranberg KG, and Dencker H: Modeling of plasma disappearance of unlabeled insulin in man. Am J Physiol 235: E577–E585, 1978. 79 Hennessy TR: Insulin secretion modelled by numerical inversion of the Laplace transform. In Proceedings of the 15th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Szeto AYJ, and Rangayyan RM, Eds. IEEE, San Diego, 1993, pp 544–545. 80 Bergman RN: Toward physiological understanding of glucose tolerance. Minimal model approach. Diabetes 38: 1512–1525, 1989. 81 Bergman RN, Ider YZ, Bowden CR, and Cobelli C: Quantitative estimation of insulin sensitivity. Am J Physiol 236: E667–E677, 1979. 82 Bergman RN, Hope ID, Yang YJ, Watanabe RM, Meador MA, Youn JH, and Ader M: Assessment of insulin sensitivity in vivo: a critical review. Diabetes/Metab Rev 5: 411–429, 1989. 83 DeFronzo RA, Tobin JD, and Andres R: Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 237: E214–E223, 1979. 84 Baynes C, Anyaoku V, Johnston DG, and Elkeles RS: Feedback inhibition of insulin secretion in type 2 diabetes. Clin Sci 81: 685–690, 1991. 85 Cavallo Perin P, Bruno A, and Nuccio P: Feedback inhibition of insulin secretion is altered in cirrhosis. J Clin Endocrinol Metab 63: 1023–1027, 1986. 86 Chideckel E, Karam JH, and Grodsky GM: Insulin inhibition of insulin secretion. N Engl J Med 307: 1084–1085, 1982. 87 Powrie JK, Smith GD, Shojaee-Moradie F, Sonksen PH, and Jones RH: Mode of action of chloroquine in patients with non-insulin-dependent diabetes mellitus. Am J Physiol 260: E897–E904, 1991. 88 Mitrakou A, Vuorinen Markkola H, Raptis G, Toft I, Mokan M, Strumph P, Pimenta W, Veneman T, Jenssen T, Bolli G, Korytkowski M, Yki-Jarvinen H, and Gerich JE: Simultaneous assessment of insulin secretion and insulin sensitivity using a hyperglycaemic clamp. J Clin Endocrinol Metab 75: 379–382, 1992. 89 O'Meara NM, Sturis J, Blackman JD, Roland DC, Van Cauter E, and Polonsky KS: Analytical problems in detecting rapid insulin secretory pulses in normal humans. Am J Physiol 264: E231–E238, 1993. 90 Finegood DT, and Bergman RN: Optimal segments: a method for smoothing tracer data to calculate metabolic fluxes. Am J Physiol 244: E472–E479, 1983. 91 Bradley DC, Steil GM, and Bergman RN: Quantitation of measurement error with Optimal Segments: basis for adaptive time course smoothing. Am J Physiol 264: E902–E911, 1993. Citing Literature Volume10, Issue2July 1994Pages 91-117 ReferencesRelatedInformation

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